Structure-property relationship in cytotoxicity and cell uptake of poly(2-oxazoline) amphiphiles

Robert Luxenhofer, Gaurav Sahay, Anita Schulz, Daria Alakhova, Tatiana K. Bronich, Rainer Jordan, Alexander V. Kabanov

Research output: Contribution to journalArticlepeer-review

125 Scopus citations

Abstract

The family of poly(2-oxazoline)s (POx) is being increasingly investigated in the context of biomedical applications. We tested the relative cytotoxicity of POx and were able to confirm that these polymers are typically not cytotoxic even at high concentrations. Furthermore, we report structure-uptake relationships of a series of amphiphilic POx block copolymers that have different architectures, molar mass and chain termini. The rate of endocytosis can be fine-tuned over a broad range by changing the polymer structure. The cellular uptake increases with the hydrophobic character of the polymers and is observed even at nanomolar concentrations. Considering the structural versatility of this class of polymers, the relative ease of preparation and their stability underlines the potential of POx as a promising platform candidate for the preparation of next-generation polymer therapeutics.

Original languageEnglish (US)
Pages (from-to)73-82
Number of pages10
JournalJournal of Controlled Release
Volume153
Issue number1
DOIs
StatePublished - Jul 15 2011

Keywords

  • amphiphilic block copolymer
  • biocompatibility
  • drug delivery
  • endocytosis
  • flow cytometry

ASJC Scopus subject areas

  • Pharmaceutical Science

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