Studies of in vivo phosphorylated proteins in BC3H-1 myocytes suggest that protein kinase C is involved in insulin action

María del C. Vila; Denise R. Cooper; John S. Davis; Mary L. Standaert; Robert V. Farese

doi:10.1016/0014-5793(89)81187-1

Studies of in vivo phosphorylated proteins in BC3H-1 myocytes suggest that protein kinase C is involved in insulin action

María del C. Vila, Denise R. Cooper, John S. Davis, Mary L. Standaert, Robert V. Farese

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Insulin (10 and 100 nM) and phorbol esters increased the phosphorylation of several proteins, including 40, 47 and 80 kDa proteins, which are markers for protein kinase C activation. Insulin effects were evident at 2 min and increased over 20 min. These findings suggest that insulin activates protein kinase C in BC3H-1 myocytes.

Original language	English (US)
Pages (from-to)	177-180
Number of pages	4
Journal	FEBS Letters
Volume	244
Issue number	1
DOIs	https://doi.org/10.1016/0014-5793(89)81187-1
State	Published - Feb 13 1989
Externally published	Yes

Keywords

Diacylglycerol
Insulin
Myocyte
Phorbol ester
Phospholipid
Protein kinase C
Protein phosphorylation

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/0014-5793(89)81187-1

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abstract = "Insulin (10 and 100 nM) and phorbol esters increased the phosphorylation of several proteins, including 40, 47 and 80 kDa proteins, which are markers for protein kinase C activation. Insulin effects were evident at 2 min and increased over 20 min. These findings suggest that insulin activates protein kinase C in BC3H-1 myocytes.",

keywords = "Diacylglycerol, Insulin, Myocyte, Phorbol ester, Phospholipid, Protein kinase C, Protein phosphorylation",

author = "Vila, {Mar{\'i}a del C.} and Cooper, {Denise R.} and Davis, {John S.} and Standaert, {Mary L.} and Farese, {Robert V.}",

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doi = "10.1016/0014-5793(89)81187-1",

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T1 - Studies of in vivo phosphorylated proteins in BC3H-1 myocytes suggest that protein kinase C is involved in insulin action

AU - Vila, María del C.

AU - Cooper, Denise R.

AU - Davis, John S.

AU - Standaert, Mary L.

AU - Farese, Robert V.

PY - 1989/2/13

Y1 - 1989/2/13

N2 - Insulin (10 and 100 nM) and phorbol esters increased the phosphorylation of several proteins, including 40, 47 and 80 kDa proteins, which are markers for protein kinase C activation. Insulin effects were evident at 2 min and increased over 20 min. These findings suggest that insulin activates protein kinase C in BC3H-1 myocytes.

AB - Insulin (10 and 100 nM) and phorbol esters increased the phosphorylation of several proteins, including 40, 47 and 80 kDa proteins, which are markers for protein kinase C activation. Insulin effects were evident at 2 min and increased over 20 min. These findings suggest that insulin activates protein kinase C in BC3H-1 myocytes.

KW - Diacylglycerol

KW - Insulin

KW - Myocyte

KW - Phorbol ester

KW - Phospholipid

KW - Protein kinase C

KW - Protein phosphorylation

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AN - SCOPUS:0024576661

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JO - FEBS Letters

JF - FEBS Letters

IS - 1

ER -

Studies of in vivo phosphorylated proteins in BC3H-1 myocytes suggest that protein kinase C is involved in insulin action

Abstract

Keywords

ASJC Scopus subject areas

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