Study of covalent binding between estrogen quinones and oligonuleotides by electrospray mass spectrometry

Richard Z. Yang, Ercole L. Cavalieri, Eleanor G. Rogan, Michael L. Gross

Research output: Contribution to conferencePaper

Abstract

The study of covalent binding between estrogen quinones (EQ) and oligonucleotides by electrospray mass spectrometry (MS) is discussed. The resulting adducts may be implicated in human breast cancer. 2,3-EQ plays an important role by bonding covalently with DNA to give stable adducts. It is found that the 2,3-EQ forms a stable adduct that can be detected by matrix assisted laser desorption ionization/time of flight (MALDI/TOF) MS.

Original languageEnglish (US)
Pages433-434
Number of pages2
StatePublished - 2002
EventProceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics - Orlando, FL, United States
Duration: Jun 2 2002Jun 6 2002

Conference

ConferenceProceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics
CountryUnited States
CityOrlando, FL
Period6/2/026/6/02

ASJC Scopus subject areas

  • Spectroscopy

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    Yang, R. Z., Cavalieri, E. L., Rogan, E. G., & Gross, M. L. (2002). Study of covalent binding between estrogen quinones and oligonuleotides by electrospray mass spectrometry. 433-434. Paper presented at Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL, United States.