Subcellular distribution and properties of intestinal histamine-metabolizing enzymes from rats, guinea pigs and rhesus monkeys

S. L. Taylor, E. R. Lieber

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

1. Histamine-N-methyltransferase (HMT) from jejunal mucosa of rats, guinea pigs and rhesus monkeys was localized in the soluble fraction. 2. Diamine oxidase (DAO) from jejunal mucosa of rats and rhesus monkeys was localized in the soluble fraction. 3. Guinea pig jejunal mucosa had no observable DAO activity. 4. The Km's observed for jejunal mucosa HMT were 33.2 μM for rat, 114 μM for rhesus monkey and 7.1 μM for guinea pig. 5. The Km's observed for jejunal mucosa DAO were 0.21 mM for rat and 0.26 mM for rhesus monkey. 6. Substrate inhibition was encountered at high substrate concentrations with rat HMT and rat and monkey DAO.

Original languageEnglish (US)
Pages (from-to)21-26
Number of pages6
JournalComparative Biochemistry and Physiology. Part C, Comparative
Volume63
Issue number1
DOIs
StatePublished - 1979

    Fingerprint

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

Cite this