Submicron amino acid particles reinforced 100% keratin biomedical films with enhanced wet properties via interfacial strengthening

Xiang Mi, Helan Xu, Yiqi Yang

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Keratin films with wet stability and strength suitable for biomedical applications were developed via reinforcement with submicron cysteine particles for improved interfaces. Keratin products regenerated from wool or human hair were widely investigated as wound dressing and tissue engineering scaffolds for their satisfactory biomedical properties. However, regenerated keratin scaffolds usually did not have good mechanical properties, and also could not stand humid or wet biological environment due to poor moisture stability. Reinforcements for keratin materials were usually polysaccharides or synthetic polymers, and thus usually had non-ideal interfacial properties due to limited compatibility. In this research, submicron cystine particles were employed to reinforce keratin films for their high compatibility with keratin and bio-safety. Transition of primary and secondary structures of keratin due to matrix-reinforcement interaction was analyzed. The keratin films showed unprecedented pliancy, good tensile properties under humid conditions and biocompatibility, and thus had good potential for biomedical engineering applications.

Original languageEnglish (US)
Pages (from-to)33-40
Number of pages8
JournalColloids and Surfaces B: Biointerfaces
Volume177
DOIs
StatePublished - May 1 2019

Keywords

  • Amino acid reinforcement
  • Biomedical
  • Keratin
  • Protein film
  • Wet property

ASJC Scopus subject areas

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

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