TY - GEN
T1 - Subthreshold linear modeling of dendritic trees
T2 - 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016
AU - Khodaei, Alireza
AU - Pierobon, Massimiliano
N1 - Publisher Copyright:
© 2016 IEEE.
PY - 2016/10/13
Y1 - 2016/10/13
N2 - The design of communication systems based on the transmission of information through neurons is envisioned as a key technology for the pervasive interconnection of future wearable and implantable devices. While previous literature has mainly focused on modeling propagation of electrochemical spikes carrying natural information through the nervous system, in recent work the authors of this paper proposed the so-called subthreshold electrical stimulation as a viable technique to propagate artificial information through neurons. This technique promises to limit the interference with natural communication processes, and it can be successfully approximated with linear models. In this paper, a novel model is proposed to account for the subthreshold stimuli propagation from the dendritic tree to the soma of a neuron. A computational approach is detailed to obtain this model for a given realistic 3D dendritic tree with an arbitrary morphology. Numerical results from the model are obtained over a stimulation signal bandwidth of 1KHz, and compared with the results of a simulation through the NEURON software.
AB - The design of communication systems based on the transmission of information through neurons is envisioned as a key technology for the pervasive interconnection of future wearable and implantable devices. While previous literature has mainly focused on modeling propagation of electrochemical spikes carrying natural information through the nervous system, in recent work the authors of this paper proposed the so-called subthreshold electrical stimulation as a viable technique to propagate artificial information through neurons. This technique promises to limit the interference with natural communication processes, and it can be successfully approximated with linear models. In this paper, a novel model is proposed to account for the subthreshold stimuli propagation from the dendritic tree to the soma of a neuron. A computational approach is detailed to obtain this model for a given realistic 3D dendritic tree with an arbitrary morphology. Numerical results from the model are obtained over a stimulation signal bandwidth of 1KHz, and compared with the results of a simulation through the NEURON software.
UR - http://www.scopus.com/inward/record.url?scp=85009121755&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85009121755&partnerID=8YFLogxK
U2 - 10.1109/EMBC.2016.7590683
DO - 10.1109/EMBC.2016.7590683
M3 - Conference contribution
C2 - 28268320
AN - SCOPUS:85009121755
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 235
EP - 238
BT - 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016
PB - Institute of Electrical and Electronics Engineers Inc.
Y2 - 16 August 2016 through 20 August 2016
ER -