Successful unrelated cord blood transplantation for homozygous α-thalassemia

Burak Gumuscu; Elizabeth I. Thompson; Alfred C. Grovas; Terrence L. Zach; Phyllis I. Warkentin; Peter F. Coccia

doi:10.1097/MPH.0b013e31827e7f6a

Successful unrelated cord blood transplantation for homozygous α-thalassemia

Burak Gumuscu, Elizabeth I. Thompson, Alfred C. Grovas, Terrence L. Zach, Phyllis I. Warkentin, Peter F. Coccia

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

A now 10-year-old Laotian female was delivered at 30-week gestation by cesarean section because of severe hydrops. Fetal blood sampling revealed homozygous α-thalassemia. After immediate resuscitation, the infant was supported with frequent red cell transfusions. At 44 months of age, she received a 5 of 6 human leukocyte antigen-matched unrelated cord blood transplantation. She was treated with phlebotomy and chelation therapy with Deferasirox for correction of hemosiderosis and has been transfusion-independent since 41 days after transplant. She is currently 6 years after transplantation with stable, 100% donor engraftment, resolved iron overload, and normal growth and development.

Original language	English (US)
Pages (from-to)	570-572
Number of pages	3
Journal	Journal of Pediatric Hematology/Oncology
Volume	35
Issue number	7
DOIs	https://doi.org/10.1097/MPH.0b013e31827e7f6a
State	Published - Oct 2013

Keywords

cord blood transplantation
homozygous α-thalassemia
hydrops fetalis
stem cell transplantation for hemoglobinopathies

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

Access to Document

10.1097/MPH.0b013e31827e7f6a

Cite this

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title = "Successful unrelated cord blood transplantation for homozygous α-thalassemia",

abstract = "A now 10-year-old Laotian female was delivered at 30-week gestation by cesarean section because of severe hydrops. Fetal blood sampling revealed homozygous α-thalassemia. After immediate resuscitation, the infant was supported with frequent red cell transfusions. At 44 months of age, she received a 5 of 6 human leukocyte antigen-matched unrelated cord blood transplantation. She was treated with phlebotomy and chelation therapy with Deferasirox for correction of hemosiderosis and has been transfusion-independent since 41 days after transplant. She is currently 6 years after transplantation with stable, 100% donor engraftment, resolved iron overload, and normal growth and development.",

keywords = "cord blood transplantation, homozygous α-thalassemia, hydrops fetalis, stem cell transplantation for hemoglobinopathies",

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AU - Gumuscu, Burak

AU - Thompson, Elizabeth I.

AU - Grovas, Alfred C.

AU - Zach, Terrence L.

AU - Warkentin, Phyllis I.

AU - Coccia, Peter F.

PY - 2013/10

Y1 - 2013/10

N2 - A now 10-year-old Laotian female was delivered at 30-week gestation by cesarean section because of severe hydrops. Fetal blood sampling revealed homozygous α-thalassemia. After immediate resuscitation, the infant was supported with frequent red cell transfusions. At 44 months of age, she received a 5 of 6 human leukocyte antigen-matched unrelated cord blood transplantation. She was treated with phlebotomy and chelation therapy with Deferasirox for correction of hemosiderosis and has been transfusion-independent since 41 days after transplant. She is currently 6 years after transplantation with stable, 100% donor engraftment, resolved iron overload, and normal growth and development.

AB - A now 10-year-old Laotian female was delivered at 30-week gestation by cesarean section because of severe hydrops. Fetal blood sampling revealed homozygous α-thalassemia. After immediate resuscitation, the infant was supported with frequent red cell transfusions. At 44 months of age, she received a 5 of 6 human leukocyte antigen-matched unrelated cord blood transplantation. She was treated with phlebotomy and chelation therapy with Deferasirox for correction of hemosiderosis and has been transfusion-independent since 41 days after transplant. She is currently 6 years after transplantation with stable, 100% donor engraftment, resolved iron overload, and normal growth and development.

KW - cord blood transplantation

KW - homozygous α-thalassemia

KW - hydrops fetalis

KW - stem cell transplantation for hemoglobinopathies

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Successful unrelated cord blood transplantation for homozygous α-thalassemia

Abstract

Keywords

ASJC Scopus subject areas

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