Sumoylation in cellular senescence and aging

L. Gong; Q. Sun; D. W.C. Li

doi:10.2174/1566524016666161223104915

Sumoylation in cellular senescence and aging

L. Gong, Q. Sun, D. W.C. Li

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

Sumoylation is a reversible post-translational modification that conjugates small peptide SUMO (small ubiquitin-like modifier) to a target protein. Global protein sumoylation and expression of components in sumoylation pathway were recently found to be altered in the process of organismal aging. In addition, key factors controlling cellular senescence are known to be sumoylated. This review will summarize current information on the function of sumoylation in cellular senescence and aging.

Original language	English (US)
Pages (from-to)	871-876
Number of pages	6
Journal	Current Molecular Medicine
Volume	16
Issue number	10
DOIs	https://doi.org/10.2174/1566524016666161223104915
State	Published - Dec 1 2016

Keywords

Aging
RB
Senescence
Sumoylation
p53

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology

Access to Document

10.2174/1566524016666161223104915

Cite this

@article{c7c99029152d4971a71e30deec26854f,

title = "Sumoylation in cellular senescence and aging",

abstract = "Sumoylation is a reversible post-translational modification that conjugates small peptide SUMO (small ubiquitin-like modifier) to a target protein. Global protein sumoylation and expression of components in sumoylation pathway were recently found to be altered in the process of organismal aging. In addition, key factors controlling cellular senescence are known to be sumoylated. This review will summarize current information on the function of sumoylation in cellular senescence and aging.",

keywords = "Aging, RB, Senescence, Sumoylation, p53",

author = "L. Gong and Q. Sun and Li, {D. W.C.}",

note = "Funding Information: L.G. and D.W-C.L. are supported by National Natural Science Foundation of China (81500738) and (81570824), as well as the fundamental funds of the State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University Publisher Copyright: {\textcopyright}2016 Bentham Science Publishers.",

year = "2016",

month = dec,

day = "1",

doi = "10.2174/1566524016666161223104915",

language = "English (US)",

volume = "16",

pages = "871--876",

journal = "Current Molecular Medicine",

issn = "1566-5240",

publisher = "Bentham Science Publishers B.V.",

number = "10",

}

TY - JOUR

T1 - Sumoylation in cellular senescence and aging

AU - Gong, L.

AU - Sun, Q.

AU - Li, D. W.C.

N1 - Funding Information: L.G. and D.W-C.L. are supported by National Natural Science Foundation of China (81500738) and (81570824), as well as the fundamental funds of the State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University Publisher Copyright: ©2016 Bentham Science Publishers.

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Sumoylation is a reversible post-translational modification that conjugates small peptide SUMO (small ubiquitin-like modifier) to a target protein. Global protein sumoylation and expression of components in sumoylation pathway were recently found to be altered in the process of organismal aging. In addition, key factors controlling cellular senescence are known to be sumoylated. This review will summarize current information on the function of sumoylation in cellular senescence and aging.

AB - Sumoylation is a reversible post-translational modification that conjugates small peptide SUMO (small ubiquitin-like modifier) to a target protein. Global protein sumoylation and expression of components in sumoylation pathway were recently found to be altered in the process of organismal aging. In addition, key factors controlling cellular senescence are known to be sumoylated. This review will summarize current information on the function of sumoylation in cellular senescence and aging.

KW - Aging

KW - RB

KW - Senescence

KW - Sumoylation

KW - p53

UR - http://www.scopus.com/inward/record.url?scp=85013966293&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85013966293&partnerID=8YFLogxK

U2 - 10.2174/1566524016666161223104915

DO - 10.2174/1566524016666161223104915

M3 - Review article

C2 - 28017139

AN - SCOPUS:85013966293

SN - 1566-5240

VL - 16

SP - 871

EP - 876

JO - Current Molecular Medicine

JF - Current Molecular Medicine

IS - 10

ER -

Sumoylation in cellular senescence and aging

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this