Sumoylation in cellular senescence and aging

L. Gong, Q. Sun, D. W.C. Li

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

Sumoylation is a reversible post-translational modification that conjugates small peptide SUMO (small ubiquitin-like modifier) to a target protein. Global protein sumoylation and expression of components in sumoylation pathway were recently found to be altered in the process of organismal aging. In addition, key factors controlling cellular senescence are known to be sumoylated. This review will summarize current information on the function of sumoylation in cellular senescence and aging.

Original languageEnglish (US)
Pages (from-to)871-876
Number of pages6
JournalCurrent Molecular Medicine
Volume16
Issue number10
DOIs
StatePublished - Dec 1 2016

Keywords

  • Aging
  • RB
  • Senescence
  • Sumoylation
  • p53

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology

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