Sumoylation in lens differentiation and pathogenesis

J. W. Xiang, Z. G. Chen, L. Gong, Y. Xiao, W. J. Qing, L. Wang, X. H. Hu, Z. X. Huang, R. L. Qi, T. H. Yang, A. P. Arrigo, L. Zhang, X. C. Tang, S. Huang, F. Y. Liu, Z. W. Luo, Y. F. Liu, Q. Sun, James W Gigantelli, Y. Z. LiuD. W C Li

Research output: Contribution to journalReview article

9 Scopus citations

Abstract

Sumoylation, a post-translational modification discovered over a decade ago, turns out to be a very important regulatory mechanism mediating multiple cellular processes. Recent studies from our laboratory and others also revealed that it plays a crucial role in regulating both differentiation and pathogenesis of the ocular lens. This review will summarize these progresses.

Original languageEnglish (US)
Pages (from-to)859-870
Number of pages12
JournalCurrent Molecular Medicine
Volume16
Issue number10
DOIs
StatePublished - Dec 1 2016

Keywords

  • Cataractogenesis
  • Differentiation
  • Lens
  • Pathogenesis
  • Sumoylation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology

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