Sumoylation pathway as potential therapeutic targets in cancer

L. Gong; R. Qi; D. W.C. Li

doi:10.2174/1566524016666161223105201

Sumoylation pathway as potential therapeutic targets in cancer

L. Gong, R. Qi, D. W.C. Li

Research output: Contribution to journal › Review article › peer-review

18 Scopus citations

Abstract

Sumoylation is a covalent protein posttranslational modification that conjugates the small ubiquitin-like peptide SUMO to substrate. Sumoylation is critically implicated in multiple biological processes, including cell proliferation, differentiation, senescence and apoptosis, etc. Therefore, it is not surprising that dysregulation of sumoylation has been implicated in tumorigenesis and different types of cancer were found to be addicted to functional sumoylation pathway. The potential role for sumoylation as a therapeutic target in caner is emerging. In this review, we summarize current knowledge regarding the involvement of sumoylation in genome stability and DNA damage response. We will further discuss the therapeutic potential of sumoylation as synthetic lethal partner and as a key signaling pathway in cancer stem cells.

Original language	English (US)
Pages (from-to)	900-905
Number of pages	6
Journal	Current Molecular Medicine
Volume	16
Issue number	10
DOIs	https://doi.org/10.2174/1566524016666161223105201
State	Published - Dec 1 2016

Keywords

Cancer stem cell
DNA damage response
Genome stability
Sumoylation
Synthetic lethality

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology

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10.2174/1566524016666161223105201

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title = "Sumoylation pathway as potential therapeutic targets in cancer",

abstract = "Sumoylation is a covalent protein posttranslational modification that conjugates the small ubiquitin-like peptide SUMO to substrate. Sumoylation is critically implicated in multiple biological processes, including cell proliferation, differentiation, senescence and apoptosis, etc. Therefore, it is not surprising that dysregulation of sumoylation has been implicated in tumorigenesis and different types of cancer were found to be addicted to functional sumoylation pathway. The potential role for sumoylation as a therapeutic target in caner is emerging. In this review, we summarize current knowledge regarding the involvement of sumoylation in genome stability and DNA damage response. We will further discuss the therapeutic potential of sumoylation as synthetic lethal partner and as a key signaling pathway in cancer stem cells.",

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T1 - Sumoylation pathway as potential therapeutic targets in cancer

AU - Gong, L.

AU - Qi, R.

AU - Li, D. W.C.

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N2 - Sumoylation is a covalent protein posttranslational modification that conjugates the small ubiquitin-like peptide SUMO to substrate. Sumoylation is critically implicated in multiple biological processes, including cell proliferation, differentiation, senescence and apoptosis, etc. Therefore, it is not surprising that dysregulation of sumoylation has been implicated in tumorigenesis and different types of cancer were found to be addicted to functional sumoylation pathway. The potential role for sumoylation as a therapeutic target in caner is emerging. In this review, we summarize current knowledge regarding the involvement of sumoylation in genome stability and DNA damage response. We will further discuss the therapeutic potential of sumoylation as synthetic lethal partner and as a key signaling pathway in cancer stem cells.

AB - Sumoylation is a covalent protein posttranslational modification that conjugates the small ubiquitin-like peptide SUMO to substrate. Sumoylation is critically implicated in multiple biological processes, including cell proliferation, differentiation, senescence and apoptosis, etc. Therefore, it is not surprising that dysregulation of sumoylation has been implicated in tumorigenesis and different types of cancer were found to be addicted to functional sumoylation pathway. The potential role for sumoylation as a therapeutic target in caner is emerging. In this review, we summarize current knowledge regarding the involvement of sumoylation in genome stability and DNA damage response. We will further discuss the therapeutic potential of sumoylation as synthetic lethal partner and as a key signaling pathway in cancer stem cells.

KW - Cancer stem cell

KW - DNA damage response

KW - Genome stability

KW - Sumoylation

KW - Synthetic lethality

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Sumoylation pathway as potential therapeutic targets in cancer

Abstract

Keywords

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