31P MRS studies of exercising human muscle at high temporal resolution

Michael D. Boska, J. A. Nelson, N. Sripathi, I. I. Pipinos, A. D. Shepard, K. M.A. Welch

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Methods for measuring mitochondrial activity from 31P magnetic resonance spectroscopy data collected during and after exercise were compared in controls, weight lifters, and peripheral vascular occlusive disease (PVOD) patients. There were trends toward increasing mitochondrial activity during exercise in order from PVOD patients, moderately active controls, highly active controls, to weight lifters. Results from PVOD patients show divergence of some measures due to 1) the non-exponential nature of phosphocreatine recovery, and 2) potential breakdown of [ADP] control of the mitochondria due to lack of oxygen (for Q(max) calculation). These results demonstrate the utility of obtaining and directly analyzing high time resolution data rather than assuming monoexponential behavior of metabolite recovery.

Original languageEnglish (US)
Pages (from-to)1145-1151
Number of pages7
JournalMagnetic Resonance in Medicine
Issue number6
StatePublished - 1999
Externally publishedYes


  • Isometric exercise
  • Mitochondrial activity
  • Muscle ATP production
  • P MRS

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


Dive into the research topics of '31P MRS studies of exercising human muscle at high temporal resolution'. Together they form a unique fingerprint.

Cite this