Abstract
Methods for measuring mitochondrial activity from 31P magnetic resonance spectroscopy data collected during and after exercise were compared in controls, weight lifters, and peripheral vascular occlusive disease (PVOD) patients. There were trends toward increasing mitochondrial activity during exercise in order from PVOD patients, moderately active controls, highly active controls, to weight lifters. Results from PVOD patients show divergence of some measures due to 1) the non-exponential nature of phosphocreatine recovery, and 2) potential breakdown of [ADP] control of the mitochondria due to lack of oxygen (for Q(max) calculation). These results demonstrate the utility of obtaining and directly analyzing high time resolution data rather than assuming monoexponential behavior of metabolite recovery.
Original language | English (US) |
---|---|
Pages (from-to) | 1145-1151 |
Number of pages | 7 |
Journal | Magnetic Resonance in Medicine |
Volume | 41 |
Issue number | 6 |
DOIs | |
State | Published - 1999 |
Externally published | Yes |
Keywords
- Isometric exercise
- Mitochondrial activity
- Muscle ATP production
- P MRS
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging