TY - JOUR
T1 - 99mTc-Tilmanocept vs. Sulfur Colloid for Sentinel Node Biopsy for Melanoma in the Head and Neck
AU - Sayal, Navdeep R.
AU - Schafer, Jeffrey
AU - Jayne, Christopher
AU - Wali, Ansar
AU - Lindau, Robert
AU - Sayles, Harlan
AU - Marr, Alissa
AU - Aurit, Sarah
AU - Lydiatt, William
AU - Holcomb, Andrew
AU - Militsakh, Oleg
AU - Coughlin, Andrew
AU - Osmolak, Angela
AU - Panwar, Aru
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Indian Association of Surgical Oncology 2023.
PY - 2024/3
Y1 - 2024/3
N2 - The objective of the study is to compare sentinel lymph node (SLN) identification rates and performance characteristics of lymphoscintigraphy using 99mTc-sulfur colloid (SC) and 99mTc-tilmanocept (TL) for head and neck cutaneous melanoma. This study is a retrospective study, conducted at a single, tertiary care cancer center. Patients underwent sentinel lymph node biopsy (SLNB) for head and neck cutaneous melanoma, using SC or TL, between October 2014 and February 2019. Differences in SLN identification rates and performance characteristics between the groups were examined using the Mann–Whitney, or Fisher’s exact test. Sixty patients underwent SLNB, of which 19 employed TL. There were no significant differences between SC vs. TL in operative duration (116 vs. 127 min, P = 0.97), radiation dose (530 vs. 547 μCi, P = 0.27), median number of SLNs removed (3 vs. 2, P = 0.32), or median follow-up (46.3 vs. 38.4 months, P = 0.11). The rates of positive SLNs (17% vs. 37%, P = 0.11), intraoperative non-localization (12% vs. 16%, P = 0.70), and false-negative SLNB (5% each, P = 1.00) were not significantly different between groups. In patients with head and neck melanoma undergoing SLNB, 99mTc-tilmanocept may not differ from 99mTc-sulfur colloid in identifying SLNs or other performance characteristics. The added expense related to 99mTc-tilmanocept and lack of favorable performance data should urge caution in its adoption and promote further examination of its value in similar patient cohorts.
AB - The objective of the study is to compare sentinel lymph node (SLN) identification rates and performance characteristics of lymphoscintigraphy using 99mTc-sulfur colloid (SC) and 99mTc-tilmanocept (TL) for head and neck cutaneous melanoma. This study is a retrospective study, conducted at a single, tertiary care cancer center. Patients underwent sentinel lymph node biopsy (SLNB) for head and neck cutaneous melanoma, using SC or TL, between October 2014 and February 2019. Differences in SLN identification rates and performance characteristics between the groups were examined using the Mann–Whitney, or Fisher’s exact test. Sixty patients underwent SLNB, of which 19 employed TL. There were no significant differences between SC vs. TL in operative duration (116 vs. 127 min, P = 0.97), radiation dose (530 vs. 547 μCi, P = 0.27), median number of SLNs removed (3 vs. 2, P = 0.32), or median follow-up (46.3 vs. 38.4 months, P = 0.11). The rates of positive SLNs (17% vs. 37%, P = 0.11), intraoperative non-localization (12% vs. 16%, P = 0.70), and false-negative SLNB (5% each, P = 1.00) were not significantly different between groups. In patients with head and neck melanoma undergoing SLNB, 99mTc-tilmanocept may not differ from 99mTc-sulfur colloid in identifying SLNs or other performance characteristics. The added expense related to 99mTc-tilmanocept and lack of favorable performance data should urge caution in its adoption and promote further examination of its value in similar patient cohorts.
KW - Melanoma
KW - Sentinel lymph node biopsy
KW - Sulfur colloid
KW - Tilmanocept
KW - Value
UR - http://www.scopus.com/inward/record.url?scp=85174743111&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85174743111&partnerID=8YFLogxK
U2 - 10.1007/s13193-023-01841-6
DO - 10.1007/s13193-023-01841-6
M3 - Article
C2 - 38511039
AN - SCOPUS:85174743111
SN - 0975-7651
VL - 15
SP - 82
EP - 87
JO - Indian Journal of Surgical Oncology
JF - Indian Journal of Surgical Oncology
IS - 1
ER -