Superoxide dismutase and cancer therapy

Melissa L. Teoh-Fitzgerald, Frederick E. Domann

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Abstract

The primary superoxide scavenger, SOD, has become an important potential therapeutic modality for cancer treatment in view of the link between reactive oxygen species (ROS) and carcinogenesis. Ironically, these same ROS also play a critical role in anticancer therapies that depend on ROS generation for their action rendering the use of SOD, in these settings, as a potential interfering factor that could decrease therapeutic efficacy. This complicating situation arises since ROS are well recognized for playing a dual role as both beneficial signaling molecules as well as deleterious damaging species in biological systems. A growing body of evidence has shown that ROS act as secondary messengers in intracellular signaling cascades, which stimulate and support the oncogenic phenotype of cancer cells. On the other hand, ROS also function as antitumorigenic species since they can induce cellular senescence and death. Therefore, the appropriate application of these antioxidant enzymes is a critical consideration in designing proper strategies for both prevention and treatment of malignant disorders. This chapter reviews evidence that suggests SOD as an emerging therapeutic agent as well as a target for cancer treatment. A discussion is also devoted to the practical challenges that limit the use of SOD manipulation as an anticancer approach.

Original languageEnglish (US)
Title of host publicationOxidative Stress in Cancer Biology and Therapy
PublisherHumana Press Inc.
Pages59-84
Number of pages26
ISBN (Electronic)9781617793974
ISBN (Print)9781617793967
DOIs
StatePublished - Jan 1 2012

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Superoxide dismutase and cancer therapy'. Together they form a unique fingerprint.

Cite this