Suppression of a lethal trisomic phenotype in Drosophila melanogaster by increased dosage of an unlinked locus

D. R. Dorer; M. A. Cadden; B. Gordesky-Gold; G. Harries; A. C. Christensen

Suppression of a lethal trisomic phenotype in Drosophila melanogaster by increased dosage of an unlinked locus

D. R. Dorer, M. A. Cadden, B. Gordesky-Gold, G. Harries, A. C. Christensen

Research output: Contribution to journal › Article › peer-review

Abstract

One of the most extreme examples of gene dosage sensitivity is the Triplo- lethal locus (Tpl) on the third chromosome of Drosophila melanogaster, which is lethal when present in either one or three copies. Increased dosage of an unlinked locus, Isis, suppresses the triplo-lethal phenotype of Tpl, but not the haplo-lethal phenotype. We have mapped Isis to the X chromosome region 7E3-8A5, and shown that the suppression is a gene dosage effect. Altered dosage of Isis in the presence of two copies of Tpl has no obvious effects. By examining the interactions between Isis dosage and Tpl we suggest that Isis does not directly repress Tpl expression, but acts downstream on the triplo-lethal phenotype of Tpl.

Original language	English (US)
Pages (from-to)	243-249
Number of pages	7
Journal	Genetics
Volume	134
Issue number	1
State	Published - 1993
Externally published	Yes

ASJC Scopus subject areas

General Medicine

Cite this

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abstract = "One of the most extreme examples of gene dosage sensitivity is the Triplo- lethal locus (Tpl) on the third chromosome of Drosophila melanogaster, which is lethal when present in either one or three copies. Increased dosage of an unlinked locus, Isis, suppresses the triplo-lethal phenotype of Tpl, but not the haplo-lethal phenotype. We have mapped Isis to the X chromosome region 7E3-8A5, and shown that the suppression is a gene dosage effect. Altered dosage of Isis in the presence of two copies of Tpl has no obvious effects. By examining the interactions between Isis dosage and Tpl we suggest that Isis does not directly repress Tpl expression, but acts downstream on the triplo-lethal phenotype of Tpl.",

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T1 - Suppression of a lethal trisomic phenotype in Drosophila melanogaster by increased dosage of an unlinked locus

AU - Dorer, D. R.

AU - Cadden, M. A.

AU - Gordesky-Gold, B.

AU - Harries, G.

AU - Christensen, A. C.

PY - 1993

Y1 - 1993

N2 - One of the most extreme examples of gene dosage sensitivity is the Triplo- lethal locus (Tpl) on the third chromosome of Drosophila melanogaster, which is lethal when present in either one or three copies. Increased dosage of an unlinked locus, Isis, suppresses the triplo-lethal phenotype of Tpl, but not the haplo-lethal phenotype. We have mapped Isis to the X chromosome region 7E3-8A5, and shown that the suppression is a gene dosage effect. Altered dosage of Isis in the presence of two copies of Tpl has no obvious effects. By examining the interactions between Isis dosage and Tpl we suggest that Isis does not directly repress Tpl expression, but acts downstream on the triplo-lethal phenotype of Tpl.

AB - One of the most extreme examples of gene dosage sensitivity is the Triplo- lethal locus (Tpl) on the third chromosome of Drosophila melanogaster, which is lethal when present in either one or three copies. Increased dosage of an unlinked locus, Isis, suppresses the triplo-lethal phenotype of Tpl, but not the haplo-lethal phenotype. We have mapped Isis to the X chromosome region 7E3-8A5, and shown that the suppression is a gene dosage effect. Altered dosage of Isis in the presence of two copies of Tpl has no obvious effects. By examining the interactions between Isis dosage and Tpl we suggest that Isis does not directly repress Tpl expression, but acts downstream on the triplo-lethal phenotype of Tpl.

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Suppression of a lethal trisomic phenotype in Drosophila melanogaster by increased dosage of an unlinked locus

Abstract

ASJC Scopus subject areas

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