Suppressors of RNA silencing encoded by plant viruses and their role in viral infections

Feng Qu, T. Jack Morris

Research output: Contribution to journalShort survey

122 Scopus citations

Abstract

RNA silencing as a robust host defense mechanism against plant viruses is generally countered by virus-encoded silencing suppressors. This strategy is now increasingly recognized to be used by animal viruses as well. We present here an overview of the common features shared by some of the better studied plant viral silencing suppressors. We then briefly describe the characteristics of the few reported animal viral suppressors, notably their extraordinary ability of cross-kingdom suppression. We next discuss the basis for biased protection of viral RNA and subviral parasites by silencing suppressors, the link between movement and silencing suppression, the influence of temperature on the outcome of viral infection and the effect of viral silencing suppressors on the microRNA pathway.

Original languageEnglish (US)
Pages (from-to)5958-5964
Number of pages7
JournalFEBS Letters
Volume579
Issue number26
DOIs
StatePublished - Oct 31 2005

Keywords

  • RNA silencing
  • Viral silencing suppressor
  • Virus-host interaction

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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