TY - JOUR
T1 - Supramolecular control of singlet oxygen generation
AU - Kashyap, Akshay
AU - Ramasamy, Elamparuthi
AU - Ramalingam, Vijayakumar
AU - Pattabiraman, Mahesh
N1 - Funding Information:
Funding: This review results partly from the project funded by Nebraska Department of Economic Development/Shabri LLC (Contract# 20-01-030). The corresponding author’s scholarly activity was supported by the National Institute of General Medical Science of the National Institutes of Health (NIH) under award number GM103427. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/5/2
Y1 - 2021/5/2
N2 - Singlet oxygen (1 O2) is the excited state electronic isomer and a reactive form of molecular oxygen, which is most efficiently produced through the photosensitized excitation of ambient triplet oxygen. Photochemical singlet oxygen generation (SOG) has received tremendous attention historically, both for its practical application as well as for the fundamental aspects of its reactivity. Applications of singlet oxygen in medicine, wastewater treatment, microbial disinfection, and synthetic chemistry are the direct results of active past research into this reaction. Such advancements were achieved through design factors focused predominantly on the photosensitizer (PS), whose photoactivity is relegated to self-regulated structure and energetics in ground and excited states. However, the relatively new supramolecular approach of dictating molecular structure through non-bonding interactions has allowed photochemists to render otherwise inactive or less effective PSs as efficient1 O2 generators. This concise and first of its kind review aims to compile progress in SOG research achieved through supramolecular photochemistry in an effort to serve as a reference for future research in this direction. The aim of this review is to highlight the value in the supramolecular photochemistry approach to tapping the unexploited technological potential within this historic reaction.
AB - Singlet oxygen (1 O2) is the excited state electronic isomer and a reactive form of molecular oxygen, which is most efficiently produced through the photosensitized excitation of ambient triplet oxygen. Photochemical singlet oxygen generation (SOG) has received tremendous attention historically, both for its practical application as well as for the fundamental aspects of its reactivity. Applications of singlet oxygen in medicine, wastewater treatment, microbial disinfection, and synthetic chemistry are the direct results of active past research into this reaction. Such advancements were achieved through design factors focused predominantly on the photosensitizer (PS), whose photoactivity is relegated to self-regulated structure and energetics in ground and excited states. However, the relatively new supramolecular approach of dictating molecular structure through non-bonding interactions has allowed photochemists to render otherwise inactive or less effective PSs as efficient1 O2 generators. This concise and first of its kind review aims to compile progress in SOG research achieved through supramolecular photochemistry in an effort to serve as a reference for future research in this direction. The aim of this review is to highlight the value in the supramolecular photochemistry approach to tapping the unexploited technological potential within this historic reaction.
KW - Cal-ixarene
KW - Cavitands
KW - Cucurbituril
KW - Cyclodextrin
KW - Near IR (NIR)
KW - Oxidation
KW - Photodynamic therapy (PDT)
KW - Photosensitizer (PS)
KW - Singlet oxygen
KW - Singlet oxygen generation (SOG)
KW - Supramolecular chemistry
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U2 - 10.3390/molecules26092673
DO - 10.3390/molecules26092673
M3 - Review article
C2 - 34063309
AN - SCOPUS:85106346282
VL - 26
JO - Molecules
JF - Molecules
SN - 1420-3049
IS - 9
M1 - 2673
ER -