Surgical imaging of pancreatic cancer using polysaccharide-delivered near infrared fluorophores

Bowen Qi, Ayrianne J. Crawford, Nicholas E. Wojtynek, Michael A. Hollingsworth, Quan P. Ly, Aaron M. Mohs

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Improved methods to determine tumor localization and disease extension are critical factors in the management of pancreatic ductal adenocarcinoma (PDAC). Thus, contrast-enhanced fluorescence-guided detection of these lesions could improve the treatment of PDAC. A current limitation to fluorescence enhancement of PDAC is non-specific signal due to the clearance of the imaging dye, e.g. indocyanine green, like the liver, spleen or other local, intraperitoneal organs where metastatic spread may be present. We report surgical imaging agents that provide strong enhancement of PDAC compared to healthy tissue, but also have significantly reduced nonspecific background signal in clearance organs of the peritoneal cavity.

Original languageEnglish (US)
Title of host publicationMolecular-Guided Surgery
Subtitle of host publicationMolecules, Devices, and Applications V
EditorsBrian W. Pogue, Sylvain Gioux
PublisherSPIE
ISBN (Electronic)9781510623668
DOIs
StatePublished - Jan 1 2019
EventMolecular-Guided Surgery: Molecules, Devices, and Applications V 2019 - San Francisco, United States
Duration: Feb 2 2019Feb 4 2019

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume10862
ISSN (Print)1605-7422

Conference

ConferenceMolecular-Guided Surgery: Molecules, Devices, and Applications V 2019
CountryUnited States
CitySan Francisco
Period2/2/192/4/19

Keywords

  • Contrast agent
  • Fluorescence
  • Hyaluronic acid
  • Image-guided surgery
  • Near infrared
  • Orthotopic
  • Pancreatic adenocarcinoma

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Qi, B., Crawford, A. J., Wojtynek, N. E., Hollingsworth, M. A., Ly, Q. P., & Mohs, A. M. (2019). Surgical imaging of pancreatic cancer using polysaccharide-delivered near infrared fluorophores. In B. W. Pogue, & S. Gioux (Eds.), Molecular-Guided Surgery: Molecules, Devices, and Applications V [108620O] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10862). SPIE. https://doi.org/10.1117/12.2507008