Surgical outcome in tuberous sclerosis complex: A multicenter survey

Deepak Madhavan, Sarah Schaffer, Alexei Yankovsky, Alexis Arzimanoglou, Florence Renaldo, Charles M. Zaroff, Josiane LaJoie, Howard L. Weiner, Eva Andermann, David N. Franz, Jennifer Leonard, Mary Connolly, Greg D. Cascino, Orrin Devinsky

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

Multicenter, retrospective analysis of 70 subjects with TSC following surgery for relief of epilepsy revealed significant associations between younger age at seizure onset, present/prior history of infantile spasms, interictal focality (bilateral versus unilateral), and absence of residual postoperative predominant tuber, and poorer postoperative outcome (p < 0.01). Ictal multifocality, mental retardation, and discordant EEG and MRI data showed a negative trend toward outcome, but were not significant.

Original languageEnglish (US)
Pages (from-to)1625-1628
Number of pages4
JournalEpilepsia
Volume48
Issue number8
DOIs
StatePublished - Aug 2007

Keywords

  • Outcome
  • Surgical
  • Tuberous sclerosis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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  • Cite this

    Madhavan, D., Schaffer, S., Yankovsky, A., Arzimanoglou, A., Renaldo, F., Zaroff, C. M., LaJoie, J., Weiner, H. L., Andermann, E., Franz, D. N., Leonard, J., Connolly, M., Cascino, G. D., & Devinsky, O. (2007). Surgical outcome in tuberous sclerosis complex: A multicenter survey. Epilepsia, 48(8), 1625-1628. https://doi.org/10.1111/j.1528-1167.2007.01112.x