Surprisingly facile C-H activation in the course of oxime-directed catalytic asymmetric hydroboration

Nathan C. Thacker, Veronika M. Shoba, Andrew E. Geis, James M. Takacs

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Abstract Deuteriu-labeling studies carried out in conjunction with investigations into the directed catalytic asymmetric hydroboration of unsaturated oxime ethers reveal a surprisingly facile ortho-metallation or σ-bond metathesis pathway that diverts the expected course of CAHB to a tandem C-H activation/hydroboration reaction pathway.

Original languageEnglish (US)
Article number45600
Pages (from-to)3306-3310
Number of pages5
JournalTetrahedron Letters
Volume56
Issue number23
DOIs
StatePublished - Dec 1 2015

Keywords

  • C-H activation
  • Directed metallation
  • Rhodium-catalyzed borylation
  • Rhodium-catalyzed hydroboration

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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