TY - JOUR
T1 - Survival of de novo and secondary acute promyelocytic leukemia
T2 - A propensity-matched analysis of the SEER database
AU - Giri, Smith
AU - Pathak, Ranjan
AU - Martin, Mike G.
AU - Bhatt, Vijaya Raj
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Prior studies demonstrated that secondary acute promyelocytic leukemia (sAPL) and de novo APL may but not consistently have similar overall survival (OS). We used the Surveillance, Epidemiology, and End Results (SEER) 13 database to compare their OS. Patients with sAPL (n = 90), compared to de novo APL (n = 1600), were more likely to be older, White and diagnosed after year 2005. Mortality rate at 1 month (28.9% vs. 23.0%, p = 0.20) and 5-year OS (42% vs. 50%, p = 0.24) was similar between sAPL and de novo APL. In a multivariate analysis, sAPL was associated with similar OS as de novo APL (hazard ratio, HR 1.11; 95% confidence interval, CI 0.78-1.58; p = 0.546). This population-based study demonstrated no difference in OS or early mortality rate between sAPL and de novo APL. sAPL can be managed very similarly to de novo APL and does not need to be excluded from clinical trials of APL.
AB - Prior studies demonstrated that secondary acute promyelocytic leukemia (sAPL) and de novo APL may but not consistently have similar overall survival (OS). We used the Surveillance, Epidemiology, and End Results (SEER) 13 database to compare their OS. Patients with sAPL (n = 90), compared to de novo APL (n = 1600), were more likely to be older, White and diagnosed after year 2005. Mortality rate at 1 month (28.9% vs. 23.0%, p = 0.20) and 5-year OS (42% vs. 50%, p = 0.24) was similar between sAPL and de novo APL. In a multivariate analysis, sAPL was associated with similar OS as de novo APL (hazard ratio, HR 1.11; 95% confidence interval, CI 0.78-1.58; p = 0.546). This population-based study demonstrated no difference in OS or early mortality rate between sAPL and de novo APL. sAPL can be managed very similarly to de novo APL and does not need to be excluded from clinical trials of APL.
KW - Acute promyelocytic leukemia
KW - early mortality
KW - overall survival
KW - secondary acute promyelocytic leukemia
UR - http://www.scopus.com/inward/record.url?scp=84955213307&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84955213307&partnerID=8YFLogxK
U2 - 10.3109/10428194.2015.1063142
DO - 10.3109/10428194.2015.1063142
M3 - Article
C2 - 26084205
AN - SCOPUS:84955213307
VL - 57
SP - 385
EP - 391
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
SN - 1042-8194
IS - 2
ER -