Susceptibilities of oral bacteria and yeast to mammalian cathelicidins

J. M. Guthmiller, K. G. Vargas, R. Srikantha, L. L. Schomberg, P. L. Weistroffer, Jr McCray, B. F. Tack

Research output: Contribution to journalArticle

56 Scopus citations


The effects of cathelicidins against oral bacteria and clinically important oral yeasts are not known. We tested the susceptibilities of Actinobacillus actinomycetemcomitans, Fusobacterium nucleatum, Porphyromonas gingivalis, Streptococcus sanguis, Candida krusei, Candida tropicalis and Candida albicans to the following cathelicidins: FALL39, SMAP29, and CAP18. SMAP29 and CAP18 were antimicrobial, whereas FALL39 did not exhibit antimicrobial activity. Future studies are needed to determine the potential use of these antimicrobial peptides in prevention and treatment of oral infections.

Original languageEnglish (US)
Pages (from-to)3216-3219
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Issue number11
StatePublished - 2001

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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    Guthmiller, J. M., Vargas, K. G., Srikantha, R., Schomberg, L. L., Weistroffer, P. L., McCray, J., & Tack, B. F. (2001). Susceptibilities of oral bacteria and yeast to mammalian cathelicidins. Antimicrobial Agents and Chemotherapy, 45(11), 3216-3219.