Susceptibility of Chinese rhesus monkeys to SIV infection

Tricia H. Burdo, Maria Cecilia G. Marcondes, Caroline M.S. Lanigan, Maria Cecilia T. Penedo, Howard S. Fox

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

The use of China-derived monkeys in AIDS research has been limited by reports of reduced susceptibility to SIV. We performed a serial passage of SIV in Chinese macaques, which resulted in a viral stock capable of inducing simian AIDS and high levels of replication in these animals. Similar to HIV in humans, SIV pathogenesis in non-human primates is not limited by geographical origin. Chinese macaques are useful in pathogenesis, vaccine, and therapeutic studies in AIDS.

Original languageEnglish (US)
Pages (from-to)1704-1706
Number of pages3
JournalAIDS
Volume19
Issue number15
DOIs
StatePublished - Oct 14 2005

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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