TY - JOUR
T1 - Susceptibility of Chinese rhesus monkeys to SIV infection
AU - Burdo, Tricia H.
AU - Marcondes, Maria Cecilia G.
AU - Lanigan, Caroline M.S.
AU - Penedo, Maria Cecilia T.
AU - Fox, Howard S.
PY - 2005/10/14
Y1 - 2005/10/14
N2 - The use of China-derived monkeys in AIDS research has been limited by reports of reduced susceptibility to SIV. We performed a serial passage of SIV in Chinese macaques, which resulted in a viral stock capable of inducing simian AIDS and high levels of replication in these animals. Similar to HIV in humans, SIV pathogenesis in non-human primates is not limited by geographical origin. Chinese macaques are useful in pathogenesis, vaccine, and therapeutic studies in AIDS.
AB - The use of China-derived monkeys in AIDS research has been limited by reports of reduced susceptibility to SIV. We performed a serial passage of SIV in Chinese macaques, which resulted in a viral stock capable of inducing simian AIDS and high levels of replication in these animals. Similar to HIV in humans, SIV pathogenesis in non-human primates is not limited by geographical origin. Chinese macaques are useful in pathogenesis, vaccine, and therapeutic studies in AIDS.
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U2 - 10.1097/01.aids.0000186823.76230.33
DO - 10.1097/01.aids.0000186823.76230.33
M3 - Article
C2 - 16184046
AN - SCOPUS:27144526262
SN - 0269-9370
VL - 19
SP - 1704
EP - 1706
JO - AIDS
JF - AIDS
IS - 15
ER -