Sustained ventricular tachycardia after repair of tetralogy of Fallot: New electrophysiologic findings

John D. Kugler, William W. Pinsky, John P. Cheatham, Philip J. Hofschire, Paul K. Mooring, William H. Fleming

Research output: Contribution to journalArticle

78 Scopus citations

Abstract

Ventricular arrhythmia originating from the outflow tract of the right ventricle is a presumed cause of late sudden death in patients after repair of tetralogy of Fallot. Exercise testing has been shown to enhance detection, and phenytoin has been shown to control ventricular arrhythmias in these patients. This study reports new findings in 3 patients who underwent electrophysiologic studies at postoperative cardiac catheterization; in each, sustained ventricular tachycardia was induced and found to originate from the inflow-septal area of the right ventricle. Using serial studies, the same sustained ventricular tachycardia was induced during therapeutic serum concentrations of phenytoin but not after propranolol. No patient had ventricular arrhythmia during a 24-hour electrocardiogram or during exercise. Although no patient had normal hemodynamic function, only 1 patient had right ventricular pressure greater than two-thirds systemic pressure. Each patient had undergone initial intracardiac repair at a relatively late age (3, 9, and 9 years).

Original languageEnglish (US)
Pages (from-to)1137-1143
Number of pages7
JournalThe American Journal of Cardiology
Volume51
Issue number7
DOIs
StatePublished - Apr 1983

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Kugler, J. D., Pinsky, W. W., Cheatham, J. P., Hofschire, P. J., Mooring, P. K., & Fleming, W. H. (1983). Sustained ventricular tachycardia after repair of tetralogy of Fallot: New electrophysiologic findings. The American Journal of Cardiology, 51(7), 1137-1143. https://doi.org/10.1016/0002-9149(83)90359-4