Swallowing dysfunction in cancer patients

Judith E. Raber-Durlacher, Mike T. Brennan, Irma M. Verdonck-De Leeuw, Rachel J. Gibson, June G. Eilers, Tuomas Waltimo, Casper P. Bots, Marisol Michelet, Thomas P. Sollecito, Tanya S. Rouleau, Aniel Sewnaik, Rene Jean Bensadoun, Monica C. Fliedner, Sol Silverman, Fred K.L. Spijkervet

Research output: Contribution to journalReview article

73 Scopus citations

Abstract

Purpose: Dysphagia (swallowing dysfunction) is a debilitating, depressing, and potentially life-threatening complication in cancer patients that is likely underreported. The present paper is aimed to review relevant dysphagia literature between 1990 and 2010 with a focus on assessment tools, prevalence, complications, and impact on quality of life in patients with a variety of different cancers, particularly in those treated with curative chemoradiation for head and neck cancer. Methods: The literature search was limited to the English language and included both MEDLINE/PubMed and EMBASE. The search focused on papers reporting dysphagia as a side effect of cancer and cancer therapy. We identified relevant literature through the primary literature search and by articles identified in references. Results: A wide range of assessment tools for dysphagia was identified. Dysphagia is related to a number of factors such as direct impact of the tumor, cancer resection, chemotherapy, and radiotherapy and to newer therapies such as epidermal growth factor receptor inhibitors. Concomitant oral complications such as xerostomia may exacerbate subjective dysphagia. Most literature focuses on head and neck cancer, but dysphagia is also common in other types of cancer. Conclusions: Swallowing impairment is a clinically relevant acute and long-term complication in patients with a wide variety of cancers. More prospective studies on the course of dysphagia and impact on quality of life from baseline to long-term follow-up after various treatment modalities, including targeted therapies, are needed.

Original languageEnglish (US)
Pages (from-to)433-443
Number of pages11
JournalSupportive Care in Cancer
Volume20
Issue number3
DOIs
StatePublished - Mar 2012

Keywords

  • Aspiration
  • Cancer
  • Chemoradiation
  • Deglutition disorders
  • Dysphagia
  • Head and neck neoplasms
  • Swallowing dysfunction

ASJC Scopus subject areas

  • Oncology

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  • Cite this

    Raber-Durlacher, J. E., Brennan, M. T., Verdonck-De Leeuw, I. M., Gibson, R. J., Eilers, J. G., Waltimo, T., Bots, C. P., Michelet, M., Sollecito, T. P., Rouleau, T. S., Sewnaik, A., Bensadoun, R. J., Fliedner, M. C., Silverman, S., & Spijkervet, F. K. L. (2012). Swallowing dysfunction in cancer patients. Supportive Care in Cancer, 20(3), 433-443. https://doi.org/10.1007/s00520-011-1342-2