Sympathoinhibitory effects of atrial natriuretic peptide in rats with heart failure

Carolyn J. Barrett; Harold D. Schultz

doi:10.1016/S1071-9164(99)91336-2

Sympathoinhibitory effects of atrial natriuretic peptide in rats with heart failure

Carolyn J. Barrett, Harold D. Schultz

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Background: It has been suggested that a blunted sympathoinhibitory response to atrial natriuretic peptide (ANP) may contribute to the elevation of sympathetic activity seen in heart failure. Methods and Results: Experiments were performed in anesthetized rats 6 to 9 weeks after coronary ligation to induce heart failure. Responses to intravenous injections of ANP (4 μg/kg) did not differ between the sham-operated (n = 11) and heart- failure (n = 7) rats. Before sinoaortic denervation, ANP decreased mean arterial pressure (MAP) by 8 mm Hg in both the heart-failure and sham rats, renal sympathetic nerve activity (RSNA) by 9% to 10% in both groups, and heart rate (HR) by 12 to 13 beats/min in both groups. After baroreceptor denervation, ANP decreased MAP by approximately 22 mm Hg, RSNA by 14%, and HR by 16 beats/min in both the heart-failure and sham rats. After vagotomy, there was no longer a significant decrease in RSNA or HR in response to ANP. Conclusion: The sympathoinhibitory effects of ANP are maintained in heart failure. This suggests that the elevated sympathetic activity observed in heart failure cannot be attributed to a blunting of the response to ANP.

Original language	English (US)
Pages (from-to)	316-323
Number of pages	8
Journal	Journal of Cardiac Failure
Volume	5
Issue number	4
DOIs	https://doi.org/10.1016/S1071-9164(99)91336-2
State	Published - Dec 1999

Keywords

Atrial natriuretic peptide
Heart failure
Rat
Renal sympathetic nerve activity

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/S1071-9164(99)91336-2

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@article{8cd96ec8b2fb4a6c98eba01bf8430592,

title = "Sympathoinhibitory effects of atrial natriuretic peptide in rats with heart failure",

abstract = "Background: It has been suggested that a blunted sympathoinhibitory response to atrial natriuretic peptide (ANP) may contribute to the elevation of sympathetic activity seen in heart failure. Methods and Results: Experiments were performed in anesthetized rats 6 to 9 weeks after coronary ligation to induce heart failure. Responses to intravenous injections of ANP (4 μg/kg) did not differ between the sham-operated (n = 11) and heart- failure (n = 7) rats. Before sinoaortic denervation, ANP decreased mean arterial pressure (MAP) by 8 mm Hg in both the heart-failure and sham rats, renal sympathetic nerve activity (RSNA) by 9% to 10% in both groups, and heart rate (HR) by 12 to 13 beats/min in both groups. After baroreceptor denervation, ANP decreased MAP by approximately 22 mm Hg, RSNA by 14%, and HR by 16 beats/min in both the heart-failure and sham rats. After vagotomy, there was no longer a significant decrease in RSNA or HR in response to ANP. Conclusion: The sympathoinhibitory effects of ANP are maintained in heart failure. This suggests that the elevated sympathetic activity observed in heart failure cannot be attributed to a blunting of the response to ANP.",

keywords = "Atrial natriuretic peptide, Heart failure, Rat, Renal sympathetic nerve activity",

author = "Barrett, {Carolyn J.} and Schultz, {Harold D.}",

note = "Funding Information: Supported in part by grant no. HL-52190 from the National Heart, Lung, and Blood Institute; and a grant from the University of Nebraska College of Medicine. C.J.B. was supported in part by a fellowship from the American Heart Association. Manuscript received January 8, 1999; revised manuscript received July 6, 1999; revised manuscript accepted July 16, 1999. Reprint requests: Harold D. Schultz, PhD, Department of Physiology {"}and Biophysics, University of Nebraska College of Medicine, 984575 Nebraska Medical Center, Omaha, NE 68198-4575. Copyright {\textcopyright} 1999 by Churchill Livingstone {\textregistered} 1071-9164/99/0504-0006510.00/0",

year = "1999",

month = dec,

doi = "10.1016/S1071-9164(99)91336-2",

language = "English (US)",

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journal = "Journal of Cardiac Failure",

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T1 - Sympathoinhibitory effects of atrial natriuretic peptide in rats with heart failure

AU - Barrett, Carolyn J.

AU - Schultz, Harold D.

N1 - Funding Information: Supported in part by grant no. HL-52190 from the National Heart, Lung, and Blood Institute; and a grant from the University of Nebraska College of Medicine. C.J.B. was supported in part by a fellowship from the American Heart Association. Manuscript received January 8, 1999; revised manuscript received July 6, 1999; revised manuscript accepted July 16, 1999. Reprint requests: Harold D. Schultz, PhD, Department of Physiology "and Biophysics, University of Nebraska College of Medicine, 984575 Nebraska Medical Center, Omaha, NE 68198-4575. Copyright © 1999 by Churchill Livingstone ® 1071-9164/99/0504-0006510.00/0

PY - 1999/12

Y1 - 1999/12

N2 - Background: It has been suggested that a blunted sympathoinhibitory response to atrial natriuretic peptide (ANP) may contribute to the elevation of sympathetic activity seen in heart failure. Methods and Results: Experiments were performed in anesthetized rats 6 to 9 weeks after coronary ligation to induce heart failure. Responses to intravenous injections of ANP (4 μg/kg) did not differ between the sham-operated (n = 11) and heart- failure (n = 7) rats. Before sinoaortic denervation, ANP decreased mean arterial pressure (MAP) by 8 mm Hg in both the heart-failure and sham rats, renal sympathetic nerve activity (RSNA) by 9% to 10% in both groups, and heart rate (HR) by 12 to 13 beats/min in both groups. After baroreceptor denervation, ANP decreased MAP by approximately 22 mm Hg, RSNA by 14%, and HR by 16 beats/min in both the heart-failure and sham rats. After vagotomy, there was no longer a significant decrease in RSNA or HR in response to ANP. Conclusion: The sympathoinhibitory effects of ANP are maintained in heart failure. This suggests that the elevated sympathetic activity observed in heart failure cannot be attributed to a blunting of the response to ANP.

AB - Background: It has been suggested that a blunted sympathoinhibitory response to atrial natriuretic peptide (ANP) may contribute to the elevation of sympathetic activity seen in heart failure. Methods and Results: Experiments were performed in anesthetized rats 6 to 9 weeks after coronary ligation to induce heart failure. Responses to intravenous injections of ANP (4 μg/kg) did not differ between the sham-operated (n = 11) and heart- failure (n = 7) rats. Before sinoaortic denervation, ANP decreased mean arterial pressure (MAP) by 8 mm Hg in both the heart-failure and sham rats, renal sympathetic nerve activity (RSNA) by 9% to 10% in both groups, and heart rate (HR) by 12 to 13 beats/min in both groups. After baroreceptor denervation, ANP decreased MAP by approximately 22 mm Hg, RSNA by 14%, and HR by 16 beats/min in both the heart-failure and sham rats. After vagotomy, there was no longer a significant decrease in RSNA or HR in response to ANP. Conclusion: The sympathoinhibitory effects of ANP are maintained in heart failure. This suggests that the elevated sympathetic activity observed in heart failure cannot be attributed to a blunting of the response to ANP.

KW - Atrial natriuretic peptide

KW - Heart failure

KW - Rat

KW - Renal sympathetic nerve activity

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JO - Journal of Cardiac Failure

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IS - 4

ER -

Sympathoinhibitory effects of atrial natriuretic peptide in rats with heart failure

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