TY - JOUR
T1 - Synaptic transmission at retinal ribbon synapses
AU - Heidelberger, Ruth
AU - Thoreson, Wallace B.
AU - Witkovsky, Paul
N1 - Funding Information:
We thank these agencies for support: NEI grants EY-03570, EY-10542, EY-12128, Research to Prevent Blindness, Gifford Foundation, Richard H. Chartrand Foundation, Esther and Joseph Klingenstein Fund. We are grateful to the following scientists for providing information and suggestions: Steve de Vries, Richard Kramer, Leon Lagnado, Katherine Luby-Phelps, Peter Lukasiewicz, Gary Matthews, Tobias Moser, Elio Raviola, Fred Rieke, Malcolm Slaughter, Jane Sullivan, Ellen Townes-Anderson, E. Brady Trexler and David Zenisek. We also thank the Rockefeller Press for permission to reproduce the diagram in Fig. 1 , and Elsevier Press for permission to modify the illustrations in Fig. 4 .
PY - 2005/11
Y1 - 2005/11
N2 - The molecular organization of ribbon synapses in photoreceptors and ON bipolar cells is reviewed in relation to the process of neurotransmitter release. The interactions between ribbon synapse-associated proteins, synaptic vesicle fusion machinery and the voltage-gated calcium channels that gate transmitter release at ribbon synapses are discussed in relation to the process of synaptic vesicle exocytosis. We describe structural and mechanistic specializations that permit the ON bipolar cell to release transmitter at a much higher rate than the photoreceptor does, under in vivo conditions. We also consider the modulation of exocytosis at photoreceptor synapses, with an emphasis on the regulation of calcium channels.
AB - The molecular organization of ribbon synapses in photoreceptors and ON bipolar cells is reviewed in relation to the process of neurotransmitter release. The interactions between ribbon synapse-associated proteins, synaptic vesicle fusion machinery and the voltage-gated calcium channels that gate transmitter release at ribbon synapses are discussed in relation to the process of synaptic vesicle exocytosis. We describe structural and mechanistic specializations that permit the ON bipolar cell to release transmitter at a much higher rate than the photoreceptor does, under in vivo conditions. We also consider the modulation of exocytosis at photoreceptor synapses, with an emphasis on the regulation of calcium channels.
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U2 - 10.1016/j.preteyeres.2005.04.002
DO - 10.1016/j.preteyeres.2005.04.002
M3 - Review article
C2 - 16027025
AN - SCOPUS:24344454662
SN - 1350-9462
VL - 24
SP - 682
EP - 720
JO - Progress in Retinal and Eye Research
JF - Progress in Retinal and Eye Research
IS - 6
ER -