Syncarcinogenic effect of the environmental pollutants cyclopenteno[CD]pyrene and benzo[a]pyrene in mouse skin

Ercole Cavalieri, Aleta Munhall, Eleanor Rogan, Shahrokh Salmasi, Kashinath Patil

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Benzo[a]pyrene (BP) and cyclopenteno[CD]pyrene (CPEP) are widespread environmental pollutants. CPEP is a relatively potent carcinogen in mouse skin with an activity second only to BP among environmental aromatic hydrocarbons. We have studied the combined application of BP and CPEP on mouse skin to determine their possible synergistic carcinogenic effect. Nine-week-old female Swiss mice in groups of 30 were treated on the back with high (H), medium (M) and low (L) doses, respectively, of 20 (H), 6.6 (M) or 2.2 (L) nmol BP or 200 (H), 66.6 (M) or 22.2 (L) nmol CPEP in 50 μl acetone twice weekly for 48 weeks. Other groups received BP-H + CPEP-H, BP-M + CPEP-M, BP-L + CPEP-L, BP-H + CPEP-L, BP-M + CPEP-L, BP-L + CPEP-H, or BP-L + CPEP-M. A significant, 3- to 7-fold syncarcinogenic effect occurred when BP-M + CPEP-M were administered together. A smaller, but significant, synergistic effect (1.2- to 3.8-fold) was also observed when BP-M + CPEP-L or BP-L + CPEP-M was applied. Because of the syncarcinogenic effect of BP and CPEP, their abundance in engine emissions and ambient air samples may present a major source of carcinogenic risk.

Original languageEnglish (US)
Pages (from-to)393-397
Number of pages5
JournalCarcinogenesis
Volume4
Issue number4
DOIs
StatePublished - Dec 1 1983

ASJC Scopus subject areas

  • Cancer Research

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