Synovial sarcoma of the head and neck: Chromosomal translocation (X;18) as a diagnostic aid

Robert A. Cihak, William M. Lydiatt, Daniel D. Lydiatt, Julia A. Bridge

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

Background. Synovial sarcoma, a rare tumor in the head and neck, has been historically diagnosed by its characteristic biphasic histologic pattern. Monophasic variants exist which can be difficult to diagnose. Methods. Two cases of synovial sarcoma of the head and neck are presented. In both cases, cytogenetic analysis was performed using standard protocols. Results. Both tumors demonstrated a chromosomal translocation, t(X;18)(p11.2;q11.2), which either made or confirmed the diagnosis. Conclusions. Synovial sarcoma contains a characteristic chromosomal translocation which is a useful diagnostic tool, especially when histologic studies are equivocal.

Original languageEnglish (US)
Pages (from-to)549-553
Number of pages5
JournalHead and Neck
Volume19
Issue number6
DOIs
StatePublished - Sep 1997

Keywords

  • Chromosome
  • Neoplasm
  • Sarcoma
  • Synovial
  • Translocation

ASJC Scopus subject areas

  • Otorhinolaryngology

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