Abstract
Despite advances in chemotherapeutic interventions for the treatment of malaria, there is a continuing need for the development of new antimalarial agents. Previous studies indicated that co-administration of chloroquine with antioxidants such as the iron chelator deferoxamine (DFO) prevented the development of persistent cognitive damage in surrogate models of cerebral malaria. The work described herein reports the syntheses and antimalarial activities of covalent conjugates of both natural (siderophores) and artificial iron chelators, namely DFO, ferricrocin and ICL-670, with antimalarial 1,2,4-trioxolanes (ozonides). All of the synthesized conjugates had potent antimalarial activities against the in vitro cultures of drug resistant and drug sensitive strains of Plasmodium falciparum. The work described herein provides the basis for future development of covalent combination of iron chelators and antimalarial chemotherapeutic agents for the treatment of cerebral malaria. Graphical abstract: [Figure not available: see fulltext.].
Original language | English (US) |
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Pages (from-to) | 315-320 |
Number of pages | 6 |
Journal | BioMetals |
Volume | 36 |
Issue number | 2 |
DOIs | |
State | Published - Apr 2023 |
Keywords
- Antimalarials
- Cerebral malaria
- Iron chelation
- Siderophore-ozonide conjugates
ASJC Scopus subject areas
- Biomaterials
- General Biochemistry, Genetics and Molecular Biology
- General Agricultural and Biological Sciences
- Metals and Alloys