Synthesis and Biological Evaluation of a Tetrahydroisoquinoline Derivative Possessing Selective β2-Adrenergic Agonist Activity

Peter F. Kador, R. Venkatraman, Dennis R. Feller, Duane D. Miller

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

This paper reports the synthesis of 4-(3,4,5-trimethoxybenzyI)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (2) and 2-(3,4-dihydroxyphenyl)-3-(3,4,5-trimethoxyphenyl)propylamine (3). The biological activity of these agents relative to that of trimetoquinol (1) in guinea pig atria and guinea pig trachea is reported. The relative activities in relaxation of guinea pig trachea is 1 > 2 > 3 while in the chronotropic response in guinea pig atria the relative order of activity is 1 > 3 ≫ 2.

Original languageEnglish (US)
Pages (from-to)891-894
Number of pages4
JournalJournal of Medicinal Chemistry
Volume20
Issue number7
DOIs
StatePublished - Jul 1 1977

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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