This paper reports the synthesis of 4-(3,4,5-trimethoxybenzyI)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (2) and 2-(3,4-dihydroxyphenyl)-3-(3,4,5-trimethoxyphenyl)propylamine (3). The biological activity of these agents relative to that of trimetoquinol (1) in guinea pig atria and guinea pig trachea is reported. The relative activities in relaxation of guinea pig trachea is 1 > 2 > 3 while in the chronotropic response in guinea pig atria the relative order of activity is 1 > 3 ≫ 2.
|Original language||English (US)|
|Number of pages||4|
|Journal||Journal of Medicinal Chemistry|
|State||Published - Jul 1 1977|
ASJC Scopus subject areas
- Molecular Medicine
- Drug Discovery