Synthesis and Biological Evaluation of Fragmented Derivatives of Tetrahydroisoquinolines. 3. Trimetoquinol Studies

Duane D. Miller; Peter F. Kador; R. Venkatraman; Dennis R. Feller

doi:10.1021/jm00228a005

Synthesis and Biological Evaluation of Fragmented Derivatives of Tetrahydroisoquinolines. 3. Trimetoquinol Studies

Duane D. Miller, Peter F. Kador, R. Venkatraman, Dennis R. Feller

Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The synthesis of l-(3,4-dihydroxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethylamine along with the N-methyl, N-ethyl, and N-isopropyl derivatives is presented as fragmented derivatives of trimetoquinol (1). Comparative pharmacological effects of these compounds to 1 are presented and discussed.

Original language	English (US)
Pages (from-to)	763-766
Number of pages	4
Journal	Journal of Medicinal Chemistry
Volume	19
Issue number	6
DOIs	https://doi.org/10.1021/jm00228a005
State	Published - Jun 1 1976

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

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abstract = "The synthesis of l-(3,4-dihydroxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethylamine along with the N-methyl, N-ethyl, and N-isopropyl derivatives is presented as fragmented derivatives of trimetoquinol (1). Comparative pharmacological effects of these compounds to 1 are presented and discussed.",

author = "Miller, {Duane D.} and Kador, {Peter F.} and R. Venkatraman and Feller, {Dennis R.}",

year = "1976",

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AU - Miller, Duane D.

AU - Kador, Peter F.

AU - Venkatraman, R.

AU - Feller, Dennis R.

PY - 1976/6/1

Y1 - 1976/6/1

N2 - The synthesis of l-(3,4-dihydroxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethylamine along with the N-methyl, N-ethyl, and N-isopropyl derivatives is presented as fragmented derivatives of trimetoquinol (1). Comparative pharmacological effects of these compounds to 1 are presented and discussed.

AB - The synthesis of l-(3,4-dihydroxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethylamine along with the N-methyl, N-ethyl, and N-isopropyl derivatives is presented as fragmented derivatives of trimetoquinol (1). Comparative pharmacological effects of these compounds to 1 are presented and discussed.

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Synthesis and Biological Evaluation of Fragmented Derivatives of Tetrahydroisoquinolines. 3. Trimetoquinol Studies

Abstract

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