Synthesis and biological evaluation of sulfonylpyridine derivatives as potential anti-chlamydia agents

Jiachen Feng, Luana Janaína de Campos, Mohamed A. Seleem, Martin Conda-Sheridan

Research output: Contribution to journalArticlepeer-review


Chlamydia trachomatis is the most prevalent sexually transmitted bacterial infection in the United States and the world. This pathogen can cause health problems ranging from trachoma (blindness) to damage of the fallopian tubes or ectopic pregnancy, which can be life-threatening if not treated properly. To this day, there is no chlamydia-specific drug on the market. Previously, we reported the activity and basic structure–activity relationships (SAR) of sulfonylpyridine molecules that possess antichlamydial action. Based on those results, we prepared a new series of derivatives. Our data indicate the new analogs can halt the growth of C. trachomatis. The lead compound, 22, was more active than our previous molecules and did not affect the growth of S. aureus and E. coli, suggesting bacterial selectivity. We performed docking studies on the presumed target, the cylindrical protease of Chlamydia. The in-silico studies partially explained the in vitro biological result as well as predicted a possible binding pose in the binding pocket. The top compound displayed a good cytotoxicity profile towards mammalian cell lines and was stable in both serum and stimulated gastric fluid. The presented data suggests the sulfonylpyridines are promising and selective anti-chlamydial compounds that merit further structural optimization.

Original languageEnglish (US)
Article number117401
JournalBioorganic and Medicinal Chemistry
StatePublished - Aug 15 2023


  • Antibacterial
  • Chlamydia
  • SAR study
  • STI

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


Dive into the research topics of 'Synthesis and biological evaluation of sulfonylpyridine derivatives as potential anti-chlamydia agents'. Together they form a unique fingerprint.

Cite this