TY - JOUR
T1 - Synthesis and characterization of star poly(ε-caprolactone)-b- poly(ethylene glycol) and poly(L-lactide)-b-poly(ethylene glycol) copolymers
T2 - Evaluation as drug delivery carriers
AU - Wang, Fei
AU - Bronich, Tatiana K.
AU - Kabanov, Alexander V.
AU - Rauh, R. David
AU - Roovers, Jacques
PY - 2008/7
Y1 - 2008/7
N2 - Two types of 32 arm star polymers incorporating amphiphilic block copolymer arms have been synthesized and characterized. The first type, stPCL-PEG 32, is composed of a polyamidoamine (PAMAM) dendrimer as the core with radiating arms having poly(ε-caprolactone) (PCL) as an inner lipophilic block in the arm and poly(ethylene glycol) (PEG) as an outer hydrophilic block. The second type, StPLA-PEG32, is similar but with poly(L-lactide) (PLA) as the inner lipophilic block. Characterization with SEC, 1H NMR, FTIR, and DSC confirmed the structure of the polymers. Micelle formation by both star copolymers was studied by fluorescence spectroscopy. The stPCL-PEG32 polymer exhibited unimolecular micelle behavior. It was capable of solubilizing hydrophobic molecules, such as pyrene, in aqueous solution, while not displaying a critical micelle concentration. In contrast, the association behavior of stPLA-PEG32 in aqueous solution was characterized by an apparent critical micelle concentration of ca. 0.01 mg/mL. The hydrophobic anticancer drug etoposide can be encapsulated in the micelles formed from both polymers. Overall, the stPCL-PEG32 polymer exhibited a higher etoposide loading capacity (up to 7.8 w/w % versus 4.3 w/w % for StPLA-PEG32) as well as facile release kinetics and is more suitable as a potential drug delivery carrier.
AB - Two types of 32 arm star polymers incorporating amphiphilic block copolymer arms have been synthesized and characterized. The first type, stPCL-PEG 32, is composed of a polyamidoamine (PAMAM) dendrimer as the core with radiating arms having poly(ε-caprolactone) (PCL) as an inner lipophilic block in the arm and poly(ethylene glycol) (PEG) as an outer hydrophilic block. The second type, StPLA-PEG32, is similar but with poly(L-lactide) (PLA) as the inner lipophilic block. Characterization with SEC, 1H NMR, FTIR, and DSC confirmed the structure of the polymers. Micelle formation by both star copolymers was studied by fluorescence spectroscopy. The stPCL-PEG32 polymer exhibited unimolecular micelle behavior. It was capable of solubilizing hydrophobic molecules, such as pyrene, in aqueous solution, while not displaying a critical micelle concentration. In contrast, the association behavior of stPLA-PEG32 in aqueous solution was characterized by an apparent critical micelle concentration of ca. 0.01 mg/mL. The hydrophobic anticancer drug etoposide can be encapsulated in the micelles formed from both polymers. Overall, the stPCL-PEG32 polymer exhibited a higher etoposide loading capacity (up to 7.8 w/w % versus 4.3 w/w % for StPLA-PEG32) as well as facile release kinetics and is more suitable as a potential drug delivery carrier.
UR - http://www.scopus.com/inward/record.url?scp=47749134158&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=47749134158&partnerID=8YFLogxK
U2 - 10.1021/bc7004285
DO - 10.1021/bc7004285
M3 - Article
C2 - 18564869
AN - SCOPUS:47749134158
SN - 1043-1802
VL - 19
SP - 1423
EP - 1429
JO - Bioconjugate Chemistry
JF - Bioconjugate Chemistry
IS - 7
ER -