Synthesis and characterization of valproic acid ester pro-drug micelles via an amphiphilic polycaprolactone block copolymer design

Suchithra A. Senevirathne; Suthida Boonsith; David Oupicky; Michael C. Biewer; Mihaela C. Stefan

doi:10.1039/c4py01808g

Synthesis and characterization of valproic acid ester pro-drug micelles via an amphiphilic polycaprolactone block copolymer design

Suchithra A. Senevirathne, Suthida Boonsith, David Oupicky, Michael C. Biewer, Mihaela C. Stefan

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The attachment of Histone deacetylase (HDAC) inhibitors via covalent bonds to biocompatible and biodegradable block copolymers provides a new research direction for cancer treatment. Herein, we report the synthesis and characterization of valproic acid ester pro-drug micelles of amphiphilic polycaprolactone block copolymers and their potential applications in drug delivery.

Original language	English (US)
Pages (from-to)	2386-2389
Number of pages	4
Journal	Polymer Chemistry
Volume	6
Issue number	13
DOIs	https://doi.org/10.1039/c4py01808g
State	Published - Apr 7 2015

ASJC Scopus subject areas

Bioengineering
Biochemistry
Polymers and Plastics
Organic Chemistry

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10.1039/c4py01808g

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abstract = "The attachment of Histone deacetylase (HDAC) inhibitors via covalent bonds to biocompatible and biodegradable block copolymers provides a new research direction for cancer treatment. Herein, we report the synthesis and characterization of valproic acid ester pro-drug micelles of amphiphilic polycaprolactone block copolymers and their potential applications in drug delivery.",

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AU - Senevirathne, Suchithra A.

AU - Boonsith, Suthida

AU - Oupicky, David

AU - Biewer, Michael C.

AU - Stefan, Mihaela C.

PY - 2015/4/7

Y1 - 2015/4/7

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AB - The attachment of Histone deacetylase (HDAC) inhibitors via covalent bonds to biocompatible and biodegradable block copolymers provides a new research direction for cancer treatment. Herein, we report the synthesis and characterization of valproic acid ester pro-drug micelles of amphiphilic polycaprolactone block copolymers and their potential applications in drug delivery.

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Synthesis and characterization of valproic acid ester pro-drug micelles via an amphiphilic polycaprolactone block copolymer design

Abstract

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