Abstract
We report the synthesis and evaluation of a series of heterobiaryl amides as positive allosteric modulators of mGluR4. Compounds 9b and 9c showed submicromolar potency at both human and rat mGluR4. In addition, both 9b and 9c were shown to be centrally penetrant in rats using nontoxic vehicles, a major advance for the mGluR4 field.
Original language | English (US) |
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Pages (from-to) | 4115-4118 |
Number of pages | 4 |
Journal | Journal of Medicinal Chemistry |
Volume | 52 |
Issue number | 14 |
DOIs | |
State | Published - Jul 23 2009 |
Externally published | Yes |
ASJC Scopus subject areas
- Molecular Medicine
- Drug Discovery