Synthesis and evaluation of scaffolds prepared from chitosan fibers for potential use in cartilage tissue engineering

Anu Subramanian, Hsin Yi Lin, David Vu, Gustavo Larsen

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Tissue engineering concepts and methodologies that employ biocompatible matrices or scaffolds have the potential to meet needs encountered in the repair of defects in articular cartilage. A desirable design parameter in the tissue engineering of cartilage in virro is the development of seeded scaffolds with appropriate structure, composition, mechanical properties and durability that are similar to normal articular cartilage. Previous methods that have used freeze drying and lyophilization techniques to make foams and hydrogels have not met the scaffold characteristics (porosity, compressive elastic modulus, permeability and viscoelastic properties), which are required of scaffolds slated for use in cartilage tissue engineering applications. Thus there is an impetus to design and develop biomimetic scaffolds that mimic the native ECM of articular cartilage, and distribute strain in a bioresponsive manner to signal seeded chondrocytes to synthesize and organize ECM to result in inaterial properties that are in range of natural cartilage. We have employed the method of electrospinning to prepare scaffolds with oriented and random fiber alignment.

Original languageEnglish (US)
Pages (from-to)117-122
Number of pages6
JournalBiomedical Sciences Instrumentation
Volume40
StatePublished - 2004

Keywords

  • Cartilage
  • Chondrocytes
  • Electrospinning
  • Nanofibers
  • Tissue engineering

ASJC Scopus subject areas

  • Biophysics
  • Medical Laboratory Technology

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