Synthesis and evaluation of water-soluble polymeric bone-targeted drug delivery systems

Dong Wang, Scott Miller, Monika Sima, Pavla Kopečková, Jindřich Kopeček

Research output: Contribution to journalArticlepeer-review

138 Scopus citations

Abstract

Four polymeric bone-targeting conjugates were synthesized based on poly(ethylene glycol) (PEG, two conjugates) and poly [N-(2-hydroxypropyl)methacrylamide] (PHPMA, two conjugates). The well-known bone-targeting compounds, alendronate and aspartic acid peptide, were used as bone-targeting moieties. Fluorescein isothiocyanate (FITC) was attached to the conjugates as a model drug for detection purposes. The bone-targeting potential of these conjugates was tested in vitro with hydroxyapatite (HA) and in mice. The data obtained indicated that these novel delivery systems could specifically accumulate in the bone tissue.

Original languageEnglish (US)
Pages (from-to)853-859
Number of pages7
JournalBioconjugate Chemistry
Volume14
Issue number5
DOIs
StatePublished - Sep 2003

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry

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