Synthesis and physicochemical studies of partially phosphate-methylated oligodeoxyribonucleotides

Serge Vinogradov, Ulysse Asseline, Thanh Thuong Nguyen

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Partially phosphate-methylated oligodeoxyribonucleotides have been synthesized on an oxalyl-CPG derivatized support using an isopropoxyacetyl group for the protection of the exocyclic amine of the nucleic bases. Hybridization properties with the target sequence have been studied by absorption spectroscopy.

Original languageEnglish (US)
Pages (from-to)5899-5902
Number of pages4
JournalTetrahedron Letters
Volume34
Issue number37
DOIs
StatePublished - Sep 10 1993

Keywords

  • absorption spectroscopy
  • phosphate-methylated oligodeoxyribonucleotides

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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