Abstract
Partially phosphate-methylated oligodeoxyribonucleotides have been synthesized on an oxalyl-CPG derivatized support using an isopropoxyacetyl group for the protection of the exocyclic amine of the nucleic bases. Hybridization properties with the target sequence have been studied by absorption spectroscopy.
Original language | English (US) |
---|---|
Pages (from-to) | 5899-5902 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 34 |
Issue number | 37 |
DOIs | |
State | Published - Sep 10 1993 |
Keywords
- absorption spectroscopy
- phosphate-methylated oligodeoxyribonucleotides
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry