Partially phosphate-methylated oligodeoxyribonucleotides have been synthesized on an oxalyl-CPG derivatized support using an isopropoxyacetyl group for the protection of the exocyclic amine of the nucleic bases. Hybridization properties with the target sequence have been studied by absorption spectroscopy.
- absorption spectroscopy
- phosphate-methylated oligodeoxyribonucleotides
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry