Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4)

Richard Williams, Kari A. Johnson, Patrick R. Gentry, Colleen M. Niswender, Charles D. Weaver, P. Jeffrey Conn, Craig W. Lindsley, Corey R. Hopkins

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

This Letter describes the synthesis and SAR of the novel positive allosteric modulator, VU0155041, a compound that has shown in vivo efficacy in rodent models of Parkinson's disease. The synthesis takes advantage of an iterative parallel synthesis approach to rapidly synthesize and evaluate a number of analogs of VU0155041.

Original languageEnglish (US)
Pages (from-to)4967-4970
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number17
DOIs
StatePublished - Sep 1 2009

Keywords

  • Allosteric modulator
  • Metabotropic glutamate receptor 4
  • PAM
  • Parkinson's disease
  • mGluR4

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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