@article{2d44cb776c45495abb918206f77bbf27,
title = "Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4)",
abstract = "This Letter describes the synthesis and SAR of the novel positive allosteric modulator, VU0155041, a compound that has shown in vivo efficacy in rodent models of Parkinson's disease. The synthesis takes advantage of an iterative parallel synthesis approach to rapidly synthesize and evaluate a number of analogs of VU0155041.",
keywords = "Allosteric modulator, Metabotropic glutamate receptor 4, PAM, Parkinson's disease, mGluR4",
author = "Richard Williams and Johnson, {Kari A.} and Gentry, {Patrick R.} and Niswender, {Colleen M.} and Weaver, {Charles D.} and Conn, {P. Jeffrey} and Lindsley, {Craig W.} and Hopkins, {Corey R.}",
note = "Funding Information: The authors thank Qingwei Luo and Rocio Zamorano for technical assistance with pharmacology assays and Emily L. Days, Tasha Nalywajko, Cheryl A. Austin and Michael Baxter Williams for their critical contributions to the HTS portion of the project and Matt Mulder, Chris Denicola and Sichen Chang for the purification of compounds utilizing the mass-directed HPLC system. This work was supported by the National Institute of Mental Health, the Michael J. Fox Foundation, the Vanderbilt Department of Pharmacology and the Vanderbilt Institute of Chemical Biology. ",
year = "2009",
month = sep,
day = "1",
doi = "10.1016/j.bmcl.2009.07.072",
language = "English (US)",
volume = "19",
pages = "4967--4970",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Ltd",
number = "17",
}