Synthesis and structural characterization of corrole and sapphyrin analogs of imidazolium-pyridine cyclophanes

Jered C. Garrison, Matthew J. Panzner, Claire A. Tessier, Wiley J. Youngs

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Dissociation of metals from medicinal agents and deposition in healthy tissue is a major problem with many metal-based pharmaceuticals. N-heterocyclic carbenes have been shown to complex more strongly than do phosphines to a variety of metals. By incorporating N-heterocyclic carbenes into the structure of a multi-donor ligand, we envision the resulting moiety to be able to retain the metals better than other ligands. We report the synthesis of three novel mixed donor imidazolium salts. The two imidazolium cyclophanes have the potential to coordinate and stabilize metals of various sizes into their inner cavity.

Original languageEnglish (US)
Article numberS08704ST
Pages (from-to)99-102
Number of pages4
JournalSynlett
Issue number1
DOIs
StatePublished - Jan 5 2005

Keywords

  • Condensation
  • Heterocycles
  • Imidazolium
  • Ligand design
  • Macrocyclic ligands

ASJC Scopus subject areas

  • Organic Chemistry

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