Synthesis, characterization, and antitumor activity of 5-iodouracil complexes

Udai P. Singh, Badri N. Singh, Animesh K. Ghose, Rakesh K. Singh, Ajit Sodhi

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Complexes of 5-iodouracil (5IU) with Mn(II), Co(II), Cu(II), Zn(II), and Cd(II) ions have been prepared, characterized, and subjected to a screening system for evaluation of antitumor activity against Sarcoma-180 (S-180) and L 929 tumor cells. The complexes were characterized by their elemental analysis, infrared spectra, electronic spectra, magnetic measurements, and powder x-ray diffraction. The antitumor activity results indicate that some complexes have good antitumor activity both in vivo and in vitro against S-180 and L 929 tumor cells.

Original languageEnglish (US)
Pages (from-to)277-282
Number of pages6
JournalJournal of Inorganic Biochemistry
Volume44
Issue number4
DOIs
StatePublished - Dec 1991

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ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

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