Synthesis of (α,α-Difluoroalkyl)phosphonates by Displacement of Primary Triflates

David B. Berkowitz, Mari Jean Eggen, Quanrong Shen, Darby G. Sloss

Research output: Contribution to journalArticlepeer-review

80 Scopus citations


Simple primary alkyl triflates and those derived from several monosaccharides are cleanly displaced by diethyl (lithiodifluoromethyl)phosphonate to provide the corresponding (α,α-difluoroalkyl)phosphonates in minutes at −78 °C.

Original languageEnglish (US)
Pages (from-to)6174-6176
Number of pages3
JournalJournal of Organic Chemistry
Issue number23
StatePublished - 1993

ASJC Scopus subject areas

  • Organic Chemistry


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