Synthesis of [1.1.1.1]Metacyclophane Macrocycle

Andrzej Rajca, Raghavakaimal Padmakumar, Donald J. Smithhisler, Shailesh R. Desai, Charles R. Ross, John J. Stezowski

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Additions of organodilithium reagents to dialdehydes allow for construction of [1.1.1.1]metacyclophane macrocycle in ∼40% yield in the ring forming step, without resort to standard high dilution techniques. The present methodology is complementary to the conventional condensations leading to phenol- and resorcinol-based cyclotetramers.

Original languageEnglish (US)
Pages (from-to)7701-7703
Number of pages3
JournalJournal of Organic Chemistry
Volume59
Issue number25
DOIs
StatePublished - Dec 1 1994

ASJC Scopus subject areas

  • Organic Chemistry

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    Rajca, A., Padmakumar, R., Smithhisler, D. J., Desai, S. R., Ross, C. R., & Stezowski, J. J. (1994). Synthesis of [1.1.1.1]Metacyclophane Macrocycle. Journal of Organic Chemistry, 59(25), 7701-7703. https://doi.org/10.1021/jo00104a027