Additions of organodilithium reagents to dialdehydes allow for construction of [188.8.131.52]metacyclophane macrocycle in ∼40% yield in the ring forming step, without resort to standard high dilution techniques. The present methodology is complementary to the conventional condensations leading to phenol- and resorcinol-based cyclotetramers.
|Original language||English (US)|
|Number of pages||3|
|Journal||Journal of Organic Chemistry|
|State||Published - Dec 1 1994|
ASJC Scopus subject areas
- Organic Chemistry