@article{25d3092163294a77ad79549d834f6eb7,
title = "Synthesis of 1,3-diarylsubstituted indazoles utilizing a Suzuki cross-coupling/deprotection/N-arylation sequence",
abstract = "Herein we report a general synthesis of 1,3-diarylsubstituted indazoles utilizing a two-step Suzuki crosscoupling/deprotection/N-arylation sequence. This procedure proceeds in excellent overall yield starting from the 3-iodo-N-Boc indazole derivative allowing for rapid access to these compounds.",
author = "Salovich, {James M.} and Lindsley, {Craig W.} and Hopkins, {Corey R.}",
note = "Funding Information: The authors warmly thank the Vanderbilt Department of Pharmacology and the NIH/MLPCN ( 5U54MH084659-02 ) for support of this research. Vanderbilt is a member of the MLPCN and houses the Vanderbilt Specialized Chemistry Center for Accelerated Probe Development. Funding Information: The Vanderbilt Specialized Chemistry Center for Accelerated Probe Development is a member of the Molecular Libraries Production Center Network (MLPCN) initiated and supported by the NIH Molecular Libraries Roadmap. 1,2 The MLPCN is a nationwide consortium of facilities that provide high-throughput small-molecule screening and medicinal chemistry expertise for the development of chemical probes for use as tools to explore biological targets or pathways for which small-molecule tools are unavailable. 1 As part of this initiative a high-throughput screen identified a 1,3-diaryl-substituted indazole compound as a potential lead ( Fig. 1 , CID, Pubchem Compound ID). Benzannulated nitrogen heterocycles are ubiquitous in pharmaceutical research. 3,4 Over the past decade, the indazole structural variant (benzo[c]pyrazole) has received much attention due to a broad range of biological activity. 5 The synthesis of the indazole core, as well as the functionalization of the indazole ring system has recently been reviewed. 6,7 ",
year = "2010",
month = jul,
day = "21",
doi = "10.1016/j.tetlet.2010.05.060",
language = "English (US)",
volume = "51",
pages = "3796--3799",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Ltd",
number = "29",
}