Synthesis of 6,7-disubstituted-5H-pyrrolo[2,3-b]pyrazines via palladium-catalyzed heteroannulation

Corey R. Hopkins, Nicola Collar

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

A concise and efficient method for the preparation of 6,7-disubstituted-5H- pyrrolo[2,3-b]pyrazines via a palladium-catalyzed heteroannulation is reported. Both conventional and microwave heating were used to perform the reactions, with the latter showing dramatically improved results.

Original languageEnglish (US)
Pages (from-to)1845-1848
Number of pages4
JournalTetrahedron Letters
Volume46
Issue number11
DOIs
StatePublished - Mar 14 2005

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Keywords

  • 6,7-Disubstituted-5H-pyrrolo[2,3-b]pyrazine
  • Cyclization
  • Heteroannulation
  • Palladium

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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