Abstract
A concise and efficient method for the preparation of 6,7-disubstituted-5H- pyrrolo[2,3-b]pyrazines via a palladium-catalyzed heteroannulation is reported. Both conventional and microwave heating were used to perform the reactions, with the latter showing dramatically improved results.
Original language | English (US) |
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Pages (from-to) | 1845-1848 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 46 |
Issue number | 11 |
DOIs | |
State | Published - Mar 14 2005 |
Externally published | Yes |
Keywords
- 6,7-Disubstituted-5H-pyrrolo[2,3-b]pyrazine
- Cyclization
- Heteroannulation
- Palladium
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry