Synthesis of 6,7-disubstituted-5H-pyrrolo[2,3-b]pyrazines via palladium-catalyzed heteroannulation

Corey R. Hopkins; Nicola Collar

doi:10.1016/j.tetlet.2005.01.105

Synthesis of 6,7-disubstituted-5H-pyrrolo[2,3-b]pyrazines via palladium-catalyzed heteroannulation

Corey R. Hopkins, Nicola Collar

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

A concise and efficient method for the preparation of 6,7-disubstituted-5H- pyrrolo[2,3-b]pyrazines via a palladium-catalyzed heteroannulation is reported. Both conventional and microwave heating were used to perform the reactions, with the latter showing dramatically improved results.

Original language	English (US)
Pages (from-to)	1845-1848
Number of pages	4
Journal	Tetrahedron Letters
Volume	46
Issue number	11
DOIs	https://doi.org/10.1016/j.tetlet.2005.01.105
State	Published - Mar 14 2005
Externally published	Yes

Keywords

6,7-Disubstituted-5H-pyrrolo[2,3-b]pyrazine
Cyclization
Heteroannulation
Palladium

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2005.01.105

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title = "Synthesis of 6,7-disubstituted-5H-pyrrolo[2,3-b]pyrazines via palladium-catalyzed heteroannulation",

abstract = "A concise and efficient method for the preparation of 6,7-disubstituted-5H- pyrrolo[2,3-b]pyrazines via a palladium-catalyzed heteroannulation is reported. Both conventional and microwave heating were used to perform the reactions, with the latter showing dramatically improved results.",

keywords = "6,7-Disubstituted-5H-pyrrolo[2,3-b]pyrazine, Cyclization, Heteroannulation, Palladium",

author = "Hopkins, {Corey R.} and Nicola Collar",

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doi = "10.1016/j.tetlet.2005.01.105",

language = "English (US)",

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AU - Hopkins, Corey R.

AU - Collar, Nicola

PY - 2005/3/14

Y1 - 2005/3/14

N2 - A concise and efficient method for the preparation of 6,7-disubstituted-5H- pyrrolo[2,3-b]pyrazines via a palladium-catalyzed heteroannulation is reported. Both conventional and microwave heating were used to perform the reactions, with the latter showing dramatically improved results.

AB - A concise and efficient method for the preparation of 6,7-disubstituted-5H- pyrrolo[2,3-b]pyrazines via a palladium-catalyzed heteroannulation is reported. Both conventional and microwave heating were used to perform the reactions, with the latter showing dramatically improved results.

KW - 6,7-Disubstituted-5H-pyrrolo[2,3-b]pyrazine

KW - Cyclization

KW - Heteroannulation

KW - Palladium

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EP - 1848

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 11

ER -

Synthesis of 6,7-disubstituted-5H-pyrrolo[2,3-b]pyrazines via palladium-catalyzed heteroannulation

Abstract

Keywords

ASJC Scopus subject areas

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