Abstract
A concise and efficient method for the preparation of 6,7-disubstituted-5H- pyrrolo[2,3-b]pyrazines via a palladium-catalyzed heteroannulation is reported. Both conventional and microwave heating were used to perform the reactions, with the latter showing dramatically improved results.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1845-1848 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 46 |
| Issue number | 11 |
| DOIs | |
| State | Published - Mar 14 2005 |
Keywords
- 6,7-Disubstituted-5H-pyrrolo[2,3-b]pyrazine
- Cyclization
- Heteroannulation
- Palladium
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry
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Cite this
Hopkins, C. R., & Collar, N. (2005). Synthesis of 6,7-disubstituted-5H-pyrrolo[2,3-b]pyrazines via palladium-catalyzed heteroannulation. Tetrahedron Letters, 46(11), 1845-1848. https://doi.org/10.1016/j.tetlet.2005.01.105