Synthesis of 6,7-disubstituted-5H-pyrrolo[2,3-b]pyrazines via palladium-catalyzed heteroannulation

Corey R. Hopkins; Nicola Collar

doi:10.1016/j.tetlet.2005.01.105

Synthesis of 6,7-disubstituted-5H-pyrrolo[2,3-b]pyrazines via palladium-catalyzed heteroannulation

Corey R. Hopkins, Nicola Collar

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

A concise and efficient method for the preparation of 6,7-disubstituted-5H- pyrrolo[2,3-b]pyrazines via a palladium-catalyzed heteroannulation is reported. Both conventional and microwave heating were used to perform the reactions, with the latter showing dramatically improved results.

Original language	English (US)
Pages (from-to)	1845-1848
Number of pages	4
Journal	Tetrahedron Letters
Volume	46
Issue number	11
DOIs	https://doi.org/10.1016/j.tetlet.2005.01.105
State	Published - Mar 14 2005
Externally published	Yes

Keywords

6,7-Disubstituted-5H-pyrrolo[2,3-b]pyrazine
Cyclization
Heteroannulation
Palladium

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1016/j.tetlet.2005.01.105

Fingerprint Dive into the research topics of 'Synthesis of 6,7-disubstituted-5H-pyrrolo[2,3-b]pyrazines via palladium-catalyzed heteroannulation'. Together they form a unique fingerprint.

Cite this

@article{b84d76f40ab14fee9802c892600986c2,

title = "Synthesis of 6,7-disubstituted-5H-pyrrolo[2,3-b]pyrazines via palladium-catalyzed heteroannulation",

abstract = "A concise and efficient method for the preparation of 6,7-disubstituted-5H- pyrrolo[2,3-b]pyrazines via a palladium-catalyzed heteroannulation is reported. Both conventional and microwave heating were used to perform the reactions, with the latter showing dramatically improved results.",

keywords = "6,7-Disubstituted-5H-pyrrolo[2,3-b]pyrazine, Cyclization, Heteroannulation, Palladium",

author = "Hopkins, {Corey R.} and Nicola Collar",

year = "2005",

month = mar,

day = "14",

doi = "10.1016/j.tetlet.2005.01.105",

language = "English (US)",

volume = "46",

pages = "1845--1848",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Limited",

number = "11",

}

TY - JOUR

T1 - Synthesis of 6,7-disubstituted-5H-pyrrolo[2,3-b]pyrazines via palladium-catalyzed heteroannulation

AU - Hopkins, Corey R.

AU - Collar, Nicola

PY - 2005/3/14

Y1 - 2005/3/14

N2 - A concise and efficient method for the preparation of 6,7-disubstituted-5H- pyrrolo[2,3-b]pyrazines via a palladium-catalyzed heteroannulation is reported. Both conventional and microwave heating were used to perform the reactions, with the latter showing dramatically improved results.

AB - A concise and efficient method for the preparation of 6,7-disubstituted-5H- pyrrolo[2,3-b]pyrazines via a palladium-catalyzed heteroannulation is reported. Both conventional and microwave heating were used to perform the reactions, with the latter showing dramatically improved results.

KW - 6,7-Disubstituted-5H-pyrrolo[2,3-b]pyrazine

KW - Cyclization

KW - Heteroannulation

KW - Palladium

UR - http://www.scopus.com/inward/record.url?scp=14044252765&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=14044252765&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2005.01.105

DO - 10.1016/j.tetlet.2005.01.105

M3 - Article

AN - SCOPUS:14044252765

VL - 46

SP - 1845

EP - 1848

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 11

ER -