Synthesis of bioreducible polycations with controlled topologies

Ye Zi You, Jun Jie Yan, Zhi Qiang Yu, David Oupicky

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Bioreducible polycations, which possess disul fi de linkages in the backbone, have appeared as promising gene delivery carriers due to their high stability in extracellular physiological condition and bioreductiontriggered release of genetic materials, as well as reduced cytotoxicity because intracellular cytosol is a reducing environment containing high level of reducing molecules such as glutathione. Here, we describe the syntheses of bioreducible polycations, and the methods for control over their topology are also presented.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
Pages121-132
Number of pages12
Volume948
DOIs
StatePublished - 2013
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume948
ISSN (Print)10643745

Keywords

  • Bioreducible polycations
  • Controlled topologies
  • Michael-Addition polymerization
  • Poly(2-(dimethylamino)ethyl methacrylate)
  • Poly(amido amine)s
  • Polyethylenimine

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Medicine(all)

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  • Cite this

    You, Y. Z., Yan, J. J., Yu, Z. Q., & Oupicky, D. (2013). Synthesis of bioreducible polycations with controlled topologies. In Methods in Molecular Biology (Vol. 948, pp. 121-132). (Methods in Molecular Biology; Vol. 948). https://doi.org/10.1007/978-1-62703-140-0-9