Synthesis of bioreducible polycations with controlled topologies

Ye Zi You, Jun Jie Yan, Fei Yu, Zhi Qiang Yu, David Oupicky

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Bioreducible polycations, which possess disulfide linkages in the backbone, have emerged as promising nucleic acid delivery carriers due to their high stability in extracellular physiological condition and bioreduction-triggered release of the genetic material. Further benefits of bioreducible polycations include decreased cytotoxicity due to intracellular reducing environment in the cytoplasm that contains high levels of reducing molecules such as glutathione. Here, we describe the synthesis of bioreducible polycations with emphasis on methods to control their topology.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages27-38
Number of pages12
DOIs
StatePublished - 2019

Publication series

NameMethods in Molecular Biology
Volume1943
ISSN (Print)1064-3745

Keywords

  • Bioreducible polycations
  • Controlled topologies
  • Michael-addition polymerization
  • Poly(2-(dimethylamino)ethyl methacrylate
  • Poly(amido amine)s
  • Polyethylenimine

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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  • Cite this

    You, Y. Z., Yan, J. J., Yu, F., Yu, Z. Q., & Oupicky, D. (2019). Synthesis of bioreducible polycations with controlled topologies. In Methods in Molecular Biology (pp. 27-38). (Methods in Molecular Biology; Vol. 1943). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-9092-4_2