Synthesis of conformationally constrained lysine analogues

Rakesh Ganorkar, Amarnath Natarajan, Ahmed Mamai, José S. Madalengoitia

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The synthesis of two conformationally constrained lysine analogues is reported. The synthesis of the novel analogue 1 based on the 3-aza-bicyclo[3.1.0]hexane system is accomplished from the known tricycle 3 in eight steps. The synthesis of the analogue 2 is accomplished in eight steps from 4-hydroxy proline. Both analogues are synthesized appropriately protected for Fmoc/Boc solid-phase peptide synthesis.

Original languageEnglish (US)
Pages (from-to)5004-5007
Number of pages4
JournalJournal of Organic Chemistry
Volume71
Issue number13
DOIs
StatePublished - Jun 23 2006

ASJC Scopus subject areas

  • Organic Chemistry

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