Synthesis of spiro-bisperoxyketals

Prasanta Ghorai, Patrick H. Dussault, Chunhua Hu

Research output: Contribution to journalArticle

63 Scopus citations

Abstract

(Chemical Equation Presented) Syntheses of spirocyclic bis-1,2-dioxolanes, bis-1,2-dioxanes, and bis-1,2-dioxepanes are achieved through intramolecular ketalizations of hydroperoxy ketones or intramolecular alkylations of gem-dihydroperoxides. The spiroperoxides have excellent thermal and chemical stability, and several display promising activity against P. falciparum.

Original languageEnglish (US)
Pages (from-to)2401-2404
Number of pages4
JournalOrganic Letters
Volume10
Issue number12
DOIs
StatePublished - 2008

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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