Synthetic redesign of plant lipid metabolism

Richard P. Haslam, Olga Sayanova, Hae Jin Kim, Edgar B. Cahoon, Johnathan A. Napier

Research output: Contribution to journalReview articlepeer-review

72 Scopus citations


Plant seed lipid metabolism is an area of intensive research, including many examples of transgenic events in which oil composition has been modified. In the selected examples described in this review, progress towards the predictive manipulation of metabolism and the reconstitution of desired traits in a non-native host is considered. The advantages of a particular oilseed crop, Camelina sativa, as a flexible and utilitarian chassis for advanced metabolic engineering and applied synthetic biology are considered, as are the issues that still represent gaps in our ability to predictably alter plant lipid biosynthesis. Opportunities to deliver useful bio-based products via transgenic plants are described, some of which represent the most complex genetic engineering in plants to date. Future prospects are considered, with a focus on the desire to transition to more (computationally) directed manipulations of metabolism.

Original languageEnglish (US)
Pages (from-to)76-86
Number of pages11
JournalThe Plant journal : for cell and molecular biology
Issue number1
StatePublished - Jul 1 2016


  • fatty acid metabolism
  • metabolic engineering
  • oil crops
  • plant biotechnology
  • predictive manipulation

ASJC Scopus subject areas

  • Genetics
  • Plant Science
  • Cell Biology


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